Browse > Article

The Function of Reactive Oxyegn Species in Bone Loss  

Yang, Mi-Hye (College of Natural Sciences, Kyungpook National University)
Park, Hyo-Jung (College of Pharmacy, Sookmyung Women's University)
Lee, Dong-Seok (College of Natural Sciences, Kyungpook National University)
Yim, Mi-Jung (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.53, no.4, 2009 , pp. 179-183 More about this Journal
Abstract
We explored the role of reactive oxygen species (ROS) in LPS-induced bone loss. LPS was shown to increase the concentration of ROS in osteoclast precursors. The antioxidant decreased osteoclast formation by LPS. Furthermore, the antioxidant decreased NFATc1 expression by LPS, suggesting that ROS mediates NFATc1 expression in the regulation of LPS-induced osteoclast formation. Finally, the antioxidant decreased LPS-induced RANKL mRNA expression in osteoblasts. Taken together, these data indicate that LPS mediates ROS to induce bone loss.
Keywords
ROS; LPS; osteoclast; osteoblast; bone loss;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J. and Suda, T. : Osteoblastic cells are involved in osteoclast formation. Endocrinology 123, 2600 (1988)   DOI   ScienceOn
2 Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., Tsuda, E., Morinaga, T., Higashio, K., Udagawa, N., Takahashi, N. and Suda, T. : Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA 95, 3597 (1998)   DOI   ScienceOn
3 Palsson-McDermott, E. M. and O'Neill, L. A. : Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113, 153 (2004)   DOI   ScienceOn
4 Suda, K., Woo, J. T., Takami, M., Sexton, P. M. and Nagai, K. : Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL. J. Cell. Physiol. 190, 101 (2002)   DOI   ScienceOn
5 Kaneko, H., Mehrotra, M., Alander, C., Lerner, U., Pilbeam, C. and Raisz, L. : Effects of prostaglandin E2 and lipopolysaccharide on osteoclastogenesis in RAW 264.7 cells. Prostaglandins Leukot. Essent. Fatty Acids. 77, 181 (2007)   DOI   ScienceOn
6 Zou, W. and Bar-Shavit, Z. : Dual modulation of osteoclast differentiation by lipopolysaccharide. J. Bone Miner. Res. 17, 1211 (2002)   DOI   ScienceOn
7 Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T. and Martin, T. J. : Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20, 345 (1999)   DOI   ScienceOn
8 Takayanagi, H. : The role of NFAT in osteoclast formation. Ann. N. Y. Acad. Sci. 1116, 227 (2007)   DOI   PUBMED   ScienceOn
9 Wong, B. R., Rho, J., Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett, F. S. 3rd, Frankel, W. N., Lee, S. Y. and Choi, Y. : TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun Nterminal kinase in T cells. J. Biol. Chem. 272, 25190 (1997)   DOI   ScienceOn
10 Nair, S. P., Meghji, S., Wilson, M., Reddi, K., White, P. and Henderson, B. : Bacterially induced bone destruction: mechanisms and misconceptions. Infect. Immun. 64, 2371 (1996)   PUBMED
11 Sato, N., Takahashi, N., Suda, K., Nakamura, M., Yamaki, M., Ninomiya, T., Kobayashi, Y., Takada, H., Shibata, K., Yamamoto, M., Takeda, K., Akira, S., Noguchi, T. and Udagawa, N. : MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL- 1alpha. J. Exp Med. 200, 601 (2004)   DOI   PUBMED   ScienceOn
12 Kikuchi, T., Matsuguchi, T., Tsuboi, N., Mitani, A., Tanaka, S., Matsuoka, M., Yamamoto, G., Hishikawa, T., Noguchi, T. and Yoshikai, Y. : Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J. Immunol. 166, 3574 (2001)   DOI
13 Coon, D., Gulati, A., Cowan, C. and He, J. : The role of cyclooxygenase-2 (COX-2) in inflammatory bone resorption. J. Endod. 33, 432 (2007)   DOI   ScienceOn
14 Erard, F. and Ryffel, B. : Toll like receptor - potential drug targets in infectious disease. Infect. Disord. Drug. Targets. 8, 221 (2008)   DOI   PUBMED   ScienceOn
15 Lacey, D. L., Timms, E., Tan, H. L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y. X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J. and Boyle, W. J. : Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165 (1998)   DOI   ScienceOn
16 Itoh, K., Udagawa, N., Kobayashi, K., Suda, K., Li, X., Takami, M., Okahashi, N., Nishihara, T. and Takahashi, N. : Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages. J. Immunol. 170, 3688 (2003)   DOI