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Effect of Meteorin on the Regulation of TSP-1 via $PKC\delta$ Signalings in Astrocytes  

Park, Soo-Youn (College of Pharmacy, Seoul National University)
Lee, Hye-Shin (College of Pharmacy, Seoul National University)
Ko, Keum-Jae (College of Pharmacy, Seoul National University)
Park, Jeong-Ae (College of Pharmacy, Seoul National University)
Publication Information
YAKHAK HOEJI / v.53, no.3, 2009 , pp. 151-155 More about this Journal
Abstract
Meteorin in astrocytes has antiangiogenic activities via thrombospondin-1 (TSP-1), however, the regulatory mechanism has been unclear. Here we report that Meteorin upregulates TSP transcriptionally through luciferase reporter assays in astrocytes. Moreover, Meteorin activates $PKC\delta$ and ERK1/2 in astrocytes. Inhibition of $PKC\delta$ and ERK1/2 activities attenuated expression of TSP-1 by Meteorin in astrocytes. We, therefore, demonstrate that Meteorin activates $PKC\delta$ signaling and, in turn, increases TSP-1 expression in astrocytes to inhibit angiogenesis in the brain.
Keywords
astrocyte; meteorin; TSP-1; $PKC\delta$; brain; thrombospondin-1;
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Times Cited By KSCI : 2  (Citation Analysis)
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