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The Cell Surface Expression of H2-M3 Does Not Directly Effect on the Killing Activity of NK Cell  

Lee, Sang-Yeol (Department of Life Science, College of Natural Sciences, Kyungwon University)
Chun, Tae-Hoon (College of Life Sciences and Biotechnology, Korea University)
Publication Information
YAKHAK HOEJI / v.53, no.3, 2009 , pp. 125-129 More about this Journal
Abstract
H2-M3 (M3) is a unique antigen presenting molecule which provides N-formylated peptide to certain type of T cells. Previous observation indicated that NK cell activity is significantly diminished during listerial infection in $H2-M3^{-/-}$ mice. To explore the possibility that M3 expression directly effect on NK cell activity, we measured NK cell activity with or without stimulation of N-formylated peptide on antigen presenting cells. Results indicated that the expression of M3 is not directly influence on NK cell activity. Further study will be focused on the indirect effect of M3 on regulating NK cell activity.
Keywords
antigen presenting molecule; H-2M3 (M3); Major histocompatibility complex molecule; NK cell; N-formylated peptide;
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