[KSCI] Korea Science Citation Index Service

1-Furan-2-yl-3-Pyridine-2-yl-Propenone Inhibits TNF- ${\apha}$ -induced Intestinal Inflammation via Suppression of MCP-1 and IL-8 Expressions in HT-29 Human Colon Epithelial Cells

Kim, Kyoung-Jin (College of Pharmacy, Yeungnam University)
Kim, Jong-Tae (College of Pharmacy, Yeungnam University)
Lee, Eung-Seok (College of Pharmacy, Yeungnam University)
Lee, Jong-Suk (College of Pharmacy, Yeungnam University)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)

Publication Information

YAKHAK HOEJI / v.52, no.5, 2008 , pp. 402-406 More about this Journal

Abstract

Previously, we have shown that 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has an anti-inflammatory activity in a rat paw-edema model. In the present study, we investigated an inhibitory effect of FPP-3 on the tumor necrosis factor (TNF)- ${\apha}$ -induced inflammatory cytokine response in HT-29 human colon epithelial cells. Treatment with FPP-3 significantly prevented the TNF- ${\apha}$ -induced attachment of leukocytes to HT-29 colon epithelial cells, which is one of the pathologic hallmarks in colon inflammation. The effect of FPP-3 was markedly superior than that of 5-aminosalicylic acid (5-ASA), a commonly used drug for the treatment of inflammatory bowel disease (IBD). The pretreatment with FPP-3 inhibited TNF- ${\apha}$ - induced monocyte chemoattractant protein (MCP)-1, interleukin (IL)-8 mRNA expressions. In addition, FPP-3 significantly suppressed TNF- ${\apha}$ -induced nuclear factor (NF)- ${\kappa}B$ transcription activity. These results demonstrate that FPP-3 modulates intestinal inflammation via suppressing the NF- ${\kappa}B$ dependent expressions of MCP-1 and IL-8, and suggest that FPP-3 may be a valuable agent for the treatment of IBD.

Keywords

1-furan-2-yl-3-pyridin-2-yl-propenone; inflammatory bowel disease; monocyte chemoattractant protein-1; interleukin-8; 5-aminosalicylic acid;

Citations & Related Records

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