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Salviae Radix Suppresses Mast Cell-mediated Allergic Response: Inhibition of Src-family Kinase  

Kim, Young-Mi (College of Pharmacy, Duksung Women's University)
Publication Information
YAKHAK HOEJI / v.52, no.5, 2008 , pp. 370-375 More about this Journal
Abstract
In this study, the anti-allergic activity and mechanim of Salviae radix (SR) were investigated. The ethanol extract of SR showed significant inhibitory effect on degranulation from antigen-stimulated mast cells and it also inhibited the expression and secretion of TNF-${\alpha}$ and IL-4 in antigen-stimulated RBL-2H3 cells. In the mast cell-mediated local animal allergy model, it suppressed the passive cutaneous anaphylaxis in a dose-dependent manner. As its mechanism of action, SR inhibited the activating phosphorylation of Syk, a downstream signaling molecule of Src-family kinase, for the activation of mast cells. The results of the study indicate that the anti-allergic activity of SR is mediated by the inhibition of Src-family kinase in mast cells.
Keywords
Salviae radix; anti-allergic activity; mast cells; Src-family kinase; Syk kinase;
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