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The Cell Regenerative Effect of Benzoic Acid Derivatives Against Chomium Trioxide-Induced Cytotoxicity  

Han, Du-Seok (Department of Oral Anatomy, School of Dentistry, Wonkwang University)
Choi, Byung-Nam (Department of Oral Anatomy, School of Dentistry, Wonkwang University)
Lee, Jae-Sug (Department of Beauty Science, Kwangju Wonmen's University)
Choi, Hwa-Jung (Natural Medicine Research Centre, Korea Research Institute of Bioscience & Biotechnology)
Baek, Seung-Hwa (Department of Herbal Resources, Professional School of Oriental Medicine, Wonkwang University)
Publication Information
YAKHAK HOEJI / v.52, no.5, 2008 , pp. 361-369 More about this Journal
Abstract
In order to evaluate the cytotoxicity of chromium trioxide, and the cell regenerative effect of phenolic acid against chromium trioxide-induced cytotoxicity, cell viability, cell adhesion activity, lactate dehydrogenase (LDH) activity, and morphological changes of cells were performed in these cultures. The toxicity of chromium trioxide (${IC}_{50}$, 44.0 ${\mu}M$) was high according to the toxic criteria. Cell regeneration of benzoic acid derivatives against ${IC}_{50}$ value of chromium trioxide in cell morphology was increased in concentration-dependent manner. These results suggest that benzoic acid derivatives may be used as a cell regenerative agent against chromium-mediated cytotoxicity.
Keywords
inhibitory effect; nickel-mediated cytotoxicity; cell viability; cell adhesion activty;
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Times Cited By KSCI : 2  (Citation Analysis)
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