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Modulation of Th1/Th2 Cytokine Secretion in Human Peripheral Blood Mononuclear Cells by Water Extract of Acanthopanax divaricatus var. albeofructus Fruits  

Lyu, Su-Yun (College of Natural Sciences, Seoul Women's University)
Noh, Bin-Na (College of Natural Sciences, Seoul Women's University)
Park, Won-Bong (College of Natural Sciences, Seoul Women's University)
Publication Information
YAKHAK HOEJI / v.52, no.1, 2008 , pp. 27-32 More about this Journal
Abstract
Water extracts of Acanthopanax divaricatus var. albeofructus (ADA) fruits were used to treat hPBMC to determine the mechanisms for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL-2, L-12, $IFN-{\gamma}$ and $TNF-{\alpha}$) and Th-2 type (IL-6, IL-8 and IL-10) were measured using ELISA. A significant increase of Th-1 type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that ADA fruit extract may influence the anticancer immune responses towards a predominance of Th-1 cytokines in the immune system.
Keywords
acanthopanax; fruits; immunomodulatory; cytokine; Th-1/Th-2; ELISA;
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Times Cited By KSCI : 2  (Citation Analysis)
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