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Process Development for Large Scale Synthesis of TRH  

Kim, Dong-Hyeon (College of Pharmacy, Yeungnam University)
Thapa, Pritam (College of Pharmacy, Yeungnam University)
Karki, Radha (College of Pharmacy, Yeungnam University)
Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University)
Lee, Eung-Seok (College of Pharmacy, Yeungnam University)
Publication Information
YAKHAK HOEJI / v.51, no.6, 2007 , pp. 490-494 More about this Journal
Abstract
TRH (thyrotropin-releasing hormone) was chemically synthesized utilizing solution phase peptide chemistry for the process development of large scaled synthesis. All the synthetic steps performed in relatively mild conditions, higher yields, easier preparations, minimum racemizations, and separation and purification by recrystallizations.
Keywords
TRH (thyrotropin-releasing hormone); process development; peptide synthesis;
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