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Effect of $18{\beta}$-Glycyrrhetinic Acid on Septic Arthritis Caused by Candida albicans  

Han, Yong-Moon (College of Pharmacy, Dongduk Women's University)
Publication Information
YAKHAK HOEJI / v.51, no.6, 2007 , pp. 476-481 More about this Journal
Abstract
A polymorphic fungus, Candida albicans, causes various forms of infections such as disseminated candidiasis and vaginitis. Recent reports indicate that the fungus is a main etiological agent for the arthritis. In search of new sources for treatment of the fungal arthritis, we examined $18{\beta}$-glycyrrhetinic acid ($18{\beta}$-GA) against C. albicans-caused septic arthritis. The compound is isolated from Glycyrrhizae Radix that is known to have various immunomodulating activities and is one of the most popular herbal medicines. For induction of animal model of a septic arthritis, mice were given an emulsion form of C. albicans cell wall mixed with Complete Freund's Adjuvant (CFA) via footpad-injection. To determine prophylactic and therapeutic effects, the component was given to the animals before or after the induction of the arthritis, respectively. Data showed that intraperitoneal administration of $18{\beta}$-GA resulted in reduction of the inflammation, indicating the component had both prophylactic and therapeutic activities. For investigation of mechanism of the $18{\beta}$-GA, inhibitory effects on NO (nitiric oxide) and on T-lymphocyte proliferation were determined. Results demonstrated that $18{\beta}$-GA suppressed NO production from LPS (lipopolysaccharide)-treated macrophages and also inhibited proliferation of Con A (concanavalin A)activated T-cells. Taken together, $18{\beta}$-GA, a pentacyclic triterpene, has anti-arthritic activity against C. albicans-caused septic arthritis, possibly by blocking NO production and T-cell suppression.
Keywords
septic arthritis; C. albicans; $18{\beta}$-GA; immunomodulating; inflammation; NO; T-cells; mice;
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1 Han, Y. : Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritis. Int. Immuno-pharmacol. 5, 1049 (2005)   DOI   PUBMED   ScienceOn
2 Lee, S. and Han, Y. : Isolation and analysis of ginkgolides compound from EGb 761. Dongduk Pharm. Res. 7, 39 (2003)
3 Choi, I. S., Kim, S. J., Kim, B. Y., Joh, J. W., Kim, Y. I., Lee, S. K., Huh, W. S., Oh, H. Y., Kim, D. J., Kim, Y. G., Kim, M. K., Ko, Y. H. and Lee, B. B. : Candida polyarthritis in a renal transplant patient: case report of a patient successfully treated with amphotericin B. Transplant Proc. 32, 1963 (2000)
4 Paniagua, R. T., Sharpe, O., Ho, R R, Chan, S. M., Chang, A., Higgins, J. R, Tomooka, B. H., Thomas, E M., Song, J. J., Goodman, S. B., Lee, D. M., Genovese, M. C, Utz, R J., Steinman, L. and Robinson, W. H. : Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. J. Clin. Invest. 116, 2633 (2006)   DOI   PUBMED
5 Gao, X., Deeb, D., Media, J., Divine, G., Jiang, H., Chapman, R. A. and Gautam, S. C. : Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Biochem. Pharmacol. 66, 2427 (2003)   DOI   ScienceOn
6 Lotito, A. E, Muscara, M. N., Kiss, M. H., Teixeira, S. A., Novaes, G. S., Laurindo, I. M., Silva, C. A. and Mello, S. B. : Nitric oxide-derived species in synovial fluid from patients with juvenile idiopathic arthritis. Rheumatol. 31, 992 (2004)
7 Nissler, K., Pohlers, D., Hckel, M., Simon, J., Brauer, R. and Kinne, R. W. : Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation. Ann. Rheum. Dis. 63, 1470 (2004)   DOI   ScienceOn
8 Bauer, H. and Marker-Hermann, E. : Therapy with nonsteroidal anti-inflammatory drugs. Orthopade. 32, 1088 (2003)   DOI   ScienceOn
9 Felson, D. T., Anderson, J. J. and Meena, R. E : Use of short-term efficacy/toxicity tradeoffs to select second-line drugs in rheumatoid arthritis: a metaanalysis of published clinical trials. Arthritis Rheum. 35, 1117 (1992)
10 Cuende, E., Barbadillo, C. E., Mazzucchelli, R., Isasi, C, Trujillo, A. and Andreu, J. L. : Candida arthritis in adult patients who are not intravenous drug addicts: report of three cases and review of the literature. Semin Arthritis Rheum. 22, 224 (1993)
11 Nissler, K., Pohlers, D., Huckel, M., Simon, J., Brauer, R. and Kinne, R. W. : Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation. Ann. Rheum. Dis. 63, 1470 (2004)   DOI   ScienceOn
12 Colic, M., Vucevic, D., Kilibarda, V, Radicevic, N. and Savic, M. : Modulatory effects of garlic extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A. Phytomedicine. 9, 117 (2002)
13 Ukil, A., Biswas, A., Das, T. and Das, R K.: 18|3-glycyrrhetinic acid triggers curative Thl response and nitiric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kB. J. Immunol. 175, 1161 (2005)   DOI   PUBMED
14 Lee, D. M. and Weinblatt, M. E.: Rheumatoid arthritis. Lancrt. 358, 903 (2001)   DOI   ScienceOn
15 Jeong, H. G., You, H., Park, S. J., Moon, A. R., Chung, Y. C, Kang, S. K. and Chun, H. K. : Hepatoprotective effects of 18$\beta$-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2EI expression. Pharmacol. Res. 46, 221 (2002)
16 Han, Y, Kozel, T. R., Zhang, M. X., MacGill, R. S., Carroll, M. C. and Cutler, J. E.: Complement is essential for protection by an lgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis. J. Immunol. 167, 1550 (2001)   DOI
17 Lerch, K., Kalteis, T., Schubert, T., Lehn, N. and Grifka, J. : Prosthetic joint infection with osteomyelitis due to Candida albicans. Mycoses. 46, 462 (2003)   DOI   ScienceOn
18 Carlo, E, Mario, R and Giogio, R : Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. FARMACO 53, 22 (1998)
19 Berg, A. J., Wolbink, G. J. van Dijk, H. and Labadie, R. R : Inhibition of human complement by glycyrrhetinic acid. Immunology 90, 115 (1997)
20 Pohlers, D., Nissler, K., Frey, O., Simon, J., Petrow, P. K., Kinne, R. W. and Brauer, R. : Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: influence on T helper cell activation. Clin. Exp. Immunol. 135, 409 (2004)   DOI   PUBMED   ScienceOn
21 Ranjan, D., Chen, C, Johnston, T. D., Jeon, H. and Nagabhushan, M. : Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkappaB activation, and IL-2 signaling. J. Surg. Res. 121, 171 (2004)   DOI   ScienceOn
22 Kinne, R. W., Brauer, R., Stuhlmuller, B., Palombo-kinne, E. and Burmester, G.-R. : Macrophages in rheumatoid arthritis. Arthritis Res. 2, 189 (2000)
23 Han, Y. and Cutler, J. E. : Antibody response that protects against disseminated candidiasis. Infect. Immun. 63, 2714 (1995)
24 Han, Y, Ulrich, M. A. and Cutler, J. E. : Candida albicans mannan extract-protein conjugates induce a protective immune response against experimental candidiasis. J. Infect. Dis. 179, 1477 (1999)
25 Azaceta, G., Olave. X, de los Martires, L. D., Delgado, C, Gutierrez, M. and Palomera, L. : Successful lipid-complexed amphotericin B treatment of Candida arthritis in a lymphoma patient. Rev. Rhum. Engl. 66, 434 (1999)