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Improvement of Memory Impairment by L-Theanine Through Inhibition of Acetylcholinesterase Activity in Mice  

Yuk, Dong-Yeon (College of Pharmacy, Chungbuk National University)
Kim, Tae-Il (College of Pharmacy, Chungbuk National University)
Park, Sang-Gi (LG Household and Health Care Research Park)
Park, Hyoung-Kook (LG Household and Health Care Research Park)
Yoon, Yeo-Kyeung (LG Household and Health Care Research Park)
Hong, Jin-Tae (LG Household and Health Care Research Park)
Publication Information
YAKHAK HOEJI / v.51, no.6, 2007 , pp. 409-414 More about this Journal
Abstract
Acetylcholinesterase (AChE) plays a role in the progression of Alzheimer's disease (AD). In this study, we examined the improving effect of L-theanine, a major amino acid in Japanese green tea (Camellia sinensis) on the scopolamine (1 mg/kg/mouse)-induced memory dysfunction in mice. Treatment with L-theanine (2, 4 mg/kg/mouse p.o.) in the drinking water for 7 days reversed the scopolamine-induced latency time and distance in the water maze test, latency time in the passive avoidance test, and inhibited AChE activity. This study suggests that L-theanine may be a useful agent for prevention of progression of AD.
Keywords
theanine; Alzheimer's disease; memory; acetylcholinesterase;
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