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Anti-oxidant and Anti-aging Activity on Saxifraga stolonifera MEERBURGH Ethanol Extract  

Yoon, Mi-Yun (Dept. of Microbiological Engineering, Konkuk University)
Lim, Hye-Won (Dept. of Life Scienace, Ewha Womans University)
Sim, Sang-Soo (College of Pharmacy, Chung-Ang University)
Choe, Tae-Boo (Dept. of Microbiological Engineering, Konkuk University)
Publication Information
YAKHAK HOEJI / v.51, no.5, 2007 , pp. 343-349 More about this Journal
Abstract
To investigate the effect of ethanol extract of Saxifraga stolonifera MEERBURGH on skin care, we measured anti-oxidant and anti-aging activity. S. stolonifera ethanol extract itself had anti-oxidant activity in a dose-dependent manner in DPPH radical scavenging. Silica dose-dependently increased the intracellular ROS generation in RAW 264.7 cells. S. stolonifera ethanol extract inhibited silica-induced intracellular superoxide anion generation, $H_2O_2$ and hydroperoxide generation in RAW 264.7 cells. S. stolonifera ethanol extract significantly inhibited both hyaluronidase and elastase activity, also significantly inhibited MMP-1(collagenase) activity as well. In NIH 3T3 fibroblast cells, S. stolonifera ethanol extract significantly increased collagen-like polymer synthesis, which suggesting the S. stolonifera ethanol extract might be used as hydration and anti-wrinkle agents. From the above results, it is suggested that the main ingredients of S. stolonifera ethanol extract play an important role in anti-oxidant and anti-aging activity.
Keywords
Saxifraga stolonifera; ROS; collagen; anti-aging;
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