Effects of Radicicol on the Metabolism of Precursor Protein in Neuroblastoma Cells |
Leem, Jae-Yoon
(College of Pharmacy, Woosuk University)
Lee, Ri-Hua (College of Pharmacy, Woosuk University) Lee, Kyung-A (College of Pharmacy, Woosuk University) Gong, Du-Gyun (College of Pharmacy, Woosuk University) Choi, Bu-Jin (College of Pharmacy, Woosuk University) Lee, Choong-Soo (College of Pharmacy, Woosuk University) Eun, Jae-Soon (College of Pharmacy, Woosuk University) |
1 | Zarotsky, V., Sramek, J. J. and Cutler, N. R. : Galantamine hydrobromide: an agent for Alzheimer's disease. Am. J. Health Syst. Pharm. 60, 446 (2003) PUBMED |
2 | Selkoe, D. J. : The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8, 447 (1998) |
3 | Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D. and Roses, A. D. : Binding of human apolipoprotein E to synthetic amyloid beta peptide isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90, 8098 (1993) |
4 | Cai, H., Wang, Y., McCarthy, D., Wen, H., Borchelt, D. R., Price, D. L. and Wong, P. C. : BACE1 is the major -secretase for generation of A peptides by neurons. Nature Neurosci. 4, 233 (2001) |
5 | Goetz, M. P., Toft, D. O., Ames, M. M. and Erlichman, C. : The Hsp90 chaperone complex as a novel target for cancer therapy. Annals of Oncology 14, 1169 (2003) DOI ScienceOn |
6 | Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke-Haerter, P. J., Smith, M. A., Perry, G. and Shimohama, S. : Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J. 16, 601 (2002) |
7 | Vellas, B. and Fitten, L. J. : Research and Practice in Alzheimer's disease. Springer Publishing Co. (2000) |
8 | Delmotte, P. and Delmotte-Plaquee, J. : A new antifungal substance of fungal origin. Nature 171, 344 (1953) |
9 | Skovronsky, D. M., Moore, D. B., MilIa, M. E., Doms, R. W. and Lee, V. M. : Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J. Biol. Chem. 275, 2568 (2000) |
10 | Selkoe, D. J. : Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399, 23 (1999) |
11 | Sugimoto, H. : Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chem. Rec. 1, 63 (2001) DOI ScienceOn |
12 | Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G. and Citron, M. : -Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735 (1999) |
13 | Lee, S. F., Shah, S., Li, H., Yu, C., Han, W. and Yu, G. : Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J. Biol. Chem. 277, 45013 (2002) |
14 | Sambamurti, K., Hardy, J., Refolo L. M. and Lahiri, D. K. : Targeting APP metabolism for the treatment of Alzheimer's disease. Drug Dev. Res. 56, 211 (2002) |
15 | Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y. Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D. S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L. S., Sorbi, S., Bruni, A., Fraser, P. and St. George-Hyslop, P. : Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407, 48 (2000) |
16 | Jann M. W. : Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease. Pharmacotherapy 20, 1 (2000) |
17 | Kinoshita, A., Fukumoto, H., Shah, T., Whelan, C. M., Irizarry, M. C. and Hyman, B. T. : Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. J. Cell. Sci. 116, 3339 (2003) DOI ScienceOn |
18 | Iqbal, K., Sisodia, S. S. and Winblad, B. : Alzheimer's Disease: Advances in Etionlogy, Pathogenesis and Therapeutics. John Wiley & Sons, Ltd. (2001) |
19 | Kang, J, Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G., Beyreuther, K. and Muller-Hill, B. : The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733 (1987) |
20 | Morris, J. C. : Classification of dementia and Alzheimer's disease. Acta Neurol. Scand. 165, 41 (1996) |
21 | Steiner, H., Winkler, E., Edbauer, D., Prokop, S., Basset, G., Yamasaki, A., Kostka, M. and Haass, C. : PEN-2 is an integral component of the -secretase complex required for coordinated expression of presenilin and nicastrin. J. Bioi. Chem. 277, 39062 (2002) |
22 | Eun, J. S., Lee, K. A., Li, R., Choi, B. J. and Leem, J. Y : The effects of geldanamycin on the metabolism of APP. submitted |
23 | Kuo, Y. M., Emmerling, M. R., Vigo-Pelfrey, C., Kasunic, T. C., Kirkpatrick, J. B., Murdoch, G. H., Ball, M. J. and Roher, A. E. : Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J. BioI. Chem. 271, 4077 (1996) |
24 | Wang, R., Sweeney, D., Gandy, S. E. and Sissodia, S. S. : The profile of soluble amyloid protein in cultured cell media. J. Biol. Chem. 271, 31894 (1996) |
25 | Leern, J. Y., Saura, C. A., Pietrzik, C., Christianson, J., Wanamaker, C., King, L. T., Veselits, M. L., Tomita, T., Gasparini, L., Iwatsubo, T., Xu, H., Green, W. N., Koo, E. H. and Thinakaran, G. : A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol. Dis. 11, 64 (2002) DOI ScienceOn |
26 | Nunan, J. and Small, D. H. : Regulation of APP cleavage by alpha-, beta- and gamma-secretases. FEBS Lett. 483, 6 (2000) |
27 | Hardy, J. and Selkoe, D. J. : The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353 (2002) |
28 | Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Sherrington, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P., St George Hyslop, P. and Selkoe, D. J. : Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 3, 67 (1997) |
29 | Takahashi, Y., Hayashi, I., Tominari, Y., Rikimaru, K., Morohashi, Y., Kan, T., Natsugari, H., Fukuyama, T., Tomita, T. and Iwatsubo, T. : Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J. Biol. Chem. 278, 18664 (2003) DOI ScienceOn |
30 | Schulte, T. W., Akinaga, S., Soga, S., Sullivan, W., Stensgard, B., Toft, D. and Neckers, L. M. : Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones 3, 100 (1998) |
31 | Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L. and Pericak-Vance, M. A. : Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921 (1993) |
32 | Tung, J. S., Davis, D. L., Anderson, J. P., Walker, D. E., Mamo, S., Jewett, N., Hom, R. K., Sinha, S., Thorsett, E. D. and John, V. : Design of substrate-based inhibitors of human beta-secretase. J. Med. Chem. 45, 259 (2002) |
33 | Prodromou, C., Roe, S. M., O'Brien, R., Ladbury, J. E., Piper, P. W. and Pearl, L. H. : Identification and structural characterization of the ATP/ADP-binding site in the HSP90 molecular chaperone, Cell 90, 65 (1997) |
34 | Braak, H., Braak, E. and Strothjohann, M. : Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neurosci Lett. 171, 1 (1994) |