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Synthesis of Urea and Thiourea Derivatives and Their Inhibitory Activities of NO Production by Activated Macrophages  

Kim, Yoon-Jung (College of Pharmacy Sookmyung Women's University)
Cheon, Ye-Jin (College of Pharmacy Sookmyung Women's University)
Lim, Hyo-Jin (College of Pharmacy Sookmyung Women's University)
Ryu, Jae-Ha (College of Pharmacy Sookmyung Women's University)
Jeon, Ra-Ok (College of Pharmacy Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.51, no.4, 2007 , pp. 246-252 More about this Journal
Abstract
Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 ${\mu}M$ of $IC_{50}$ value.
Keywords
urea; thiourea; nitric oxide; iNOS; indole; benzoxazole;
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