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Antilipoperoxidant Activity of Antraquinone and Stilbene from Polygonum cuspidatum  

Joo, Si-Mong (College of Pharmacy, Sookmyung Women's University)
Lee, Min-Won (College of Pharmacy, Chung-Ang University)
Yang, Ki-Sook (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.51, no.2, 2007 , pp. 140-144 More about this Journal
Abstract
Polygonum cuspidatum has been used as treatments of dermatitis, gonorrhea, inflammation, and hyperlipidaemia in traditional medicine. We examined liver protective effect on CCl$_4$ inducing hepatotoxicity and anti-oxidative activity by TBA method. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin 8-O-${\beta}$-D-glucopyranoside (compound 1), and trans-resveratrol 3-O-${\beta}$-D-glucopyranoside (compound 2). Compounds 1 and 2 enhanced the inhibition of anti-lipid peroxidative effects in liver homogenate. In chemical parameters obtained from serum analysis, compounds 1 and 2 also revealed significant decrease in hepatotoxicity. These results suggested that the antraquinone and stilbene which were isolated from Polygonum cuspidatum might be used as therapeutic agent of hepatitis.
Keywords
Polygonum cuspidatum; emodin 8-O-${\beta}$-D -glucopyranoside; trans-resveratrol 3-O-${\beta}$-D -glucopyranoside; hepatotoxicity;
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