Hepatoprotective Activities of Daidzin, Daidzein, Genistein and Puerarin in Primary Cultured Rat Hepatocytes
![]() |
Park, Jin-Goo
(College of Pharmacy, Sungkyunkwan University)
Cheon, Ho-Joon (College of Pharmacy, Sungkyunkwan University) Kim, Yeong-Shik (College of Pharmacy, Seoul National University) Kang, Sam-Sik (College of Pharmacy, Seoul National University) Choi, Jae-Sue (Faculty of Food Science and Biotechnology, Pukyong National University) Lee, Sun-Mee (College of Pharmacy, Sungkyunkwan University) |
1 | Zhang, S., Ji, G. and Liu, J. : Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J. Nutr. Biochem. 17, 485 (2006) DOI ScienceOn |
2 | Kiso, Y., Tohkin, M. and Hikino, H. : Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes. Planta Med. 49, 222 (1983) |
3 | Mofty, S. K., Scrutton, M. C., Serroni, A., Nicolini, C. and Farber, J. L. : Early, reversible plasma membrane injury in galactosamine-induced liver cell death. Am. J. Pathol. 79, 579 (1975) |
4 | Rush, G. F., Gorski, J. R., Ripple, M. G., Sowinski, J., Bugelski, P. and Hewitt, W. R. : Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes. Toxicol. Appl. Pharmacol. 78, 473 (1968) |
5 | Kleinman, H. K., McGoodwin, E. B., Rennard, S. I. and Martin, G. R. : Preparation of collagen substrates for cell attachment : effect of collagen concentration and phosphate buffer. Anal. Biochem. 94, 308 (1979) |
6 | Esterbauer, H., Zollner, H. and Schur, R. J. : Hydroxyalkenals; cytotoxic products of lipidperoxidation. Science Biochem. 1, 311 (1988) |
7 |
Mujumdar, A. M., Upadhye, A. S. and Pradhan, A. M. : Effect of Azadirachta indica leaf extract on |
8 | Recknagel, R. O. and Glende, E. A. : Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Crit. Rev. Toxicol. 2, 263 (1973) |
9 | Berry, M. N. and Friend, D. S. : High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J. Cell Biol. 43, 506 (1969) |
10 | Kinjo, J. E., Furusawa, J. I., Baba, J., Takeshita, T., Yamasaki, M. and Nohara, T. : Studies on the constituents of Pueraria lobata III. Isoflavonoids and related compounds in the roots and the voluble stems. Chem. Pharm. Bull. 35, 4846 (1987) |
11 | Decker, K. and Keppler, D. : Galactosamine-induced liver injury. In Popper, H. and Schaffiner, F. (Eds.), Progress in Liver Disease, Grune, Stratton, New York, p. 183 (1972) |
12 | Recknagel, R. O. : Carbon tetrachloride hepatotoxicity. Pharmacol. Rev. 19, 145 (1967) |
13 | Reutter, W., Keppler, D., Lesch, R. and Decker, K. : Glycoprotein metabolism in galactosamine-induced hepatitis. Verh. Dtsch. Ges. Inn. Med. 75, 363 (1969) |
14 | Keung, W. M. and Vallee, B. L. : Therapeutic lessons from traditional oriental medicine to contemporary occidental phamacology. EXS 71, 371 (1994) |
15 | Kang, K. A., Chae, S., Koh, Y. S., Kim, J. S., Lee, J. H., You, H. J. and Hyun, J. W. : Protective effect of Puerariae radix on oxidative stress induced by hydrogen peroxide and streptozotocin. Biol. Pharm. Bull. 28, 1154 (2005) DOI ScienceOn |
16 | Clawson, G. A. : Mechanism of carbon tetrachloride hepatotoxicity. Pathol. Immunopathol. Res. 8, 104 (1989) |
17 | Vaca, C. E., Vodicka, P. and Hemminki, K. : Determination of malonaldehyde-modified 2'-deoxyguanosine-3'-monophosphate and DNA by 32P-postlabelling. Carcinogenesis 13, 593 (1992) |
18 | Kiso, Y., Tohkin, M. and Hikino, H. : Assay method for antihepatotoxic activity using galactosamine-induced cytotoxicity in primary-cultured hepatocytes. J. Nat. Prod. 46, 841 (1983) |
19 | Tseng, T. H., Wang, C. J., Kao, E. S. and Chu, H. Y. : Hibiscus protocatechuic acid protects against oxidative damage induced by tert-butylhydroperoxide in rat primary hepatocytes. Chem. Biol. Interact. 101, 137 (1996) |
20 | Yan, L. P., Chan, S. W., Chan, A. S., Chen, S. L., Ma, X. J. and Xu, H. X. : Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sci. 79, 324 (2006) DOI ScienceOn |
21 | Lee, Y. M., Choi, J. S., Kim, M. H., Jung, M. H., Lee, Y. S. and Song, J. H. : Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. Nutrition 22, 956 (2006) DOI ScienceOn |
22 | 생약학교재편찬위원회 : 생약학, 제5판, 동명사, 서울 p. 210 (2003) |
23 | Mossmann, T. : Rapid colorimetric assay for cellular growth and survival : application to proliferative and cytotoxic assays. Immunol. Methods 65, 55 (1983) |
24 | 송진호, 박미정, 김은, 김영중 : 인삼 분획물이 Galactosamine에 의하여 손상된 일차배양한 흰쥐의 간세포에 미치는 영향. 약학회지 34, 341 (1990) |
25 | Keppler, D., Lesch, R., Reutter, W. and Decker, K. : Experimental hepatitis induced by galactosamine. Exp. Mol. Pathol. 9, 279 (1968) |
26 | Keung, W. M. and Vallee, B. L. : Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria. Proc. Natl. Acad. Sci. USA 95, 2198 (1998) |
![]() |