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Antifibrotic Effects of Oriental Herbs Extraction on Liver Cirrhosis  

Yu, Byung-Soo (Division of Nanobiochemistry, Wonkwang University)
Lee, Jong-Hyung (Division of Nanobiochemistry, Wonkwang University)
Cho, Syung-Eun (Division of Nanobiochemistry, Wonkwang University)
Baek, Seung-Hwa (Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
YAKHAK HOEJI / v.51, no.1, 2007 , pp. 7-12 More about this Journal
Abstract
Hepatic cirrhosis is an important feature of chronic liver disease. Liver cirrhosis is characterized by hyperaccumulation of fibrous tissue components and is commonly observed in latter or terminal states of chronic hepatic disease. The antifibrotic effects on liver cirrhosis by oriental herbs extraction material were examined in bile duct ligated rats. Oriental herbs extraction (0.99 mg/kg rat weight/day) was administrated to cirrohotic rats for 4 weeks. Liver collagen content of bile duct ligated rats was significantly increased. And liver histology showed collagen fiber deposition was increased as well as the normal architecture was lost with large zone of necrosis being observed. Herbs extraction administrated rats showed significantly decreased liver collagen content, accumulation of collagen fiber in histological analysis, and biochemical markers of hepatic diseases. Those results demonstrate the usefulness of herbs extraction materials as an antifibrotic agent for liver cirrhosis.
Keywords
er cirrhosis; collagen accumulation; bile duct ligation;
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