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Relationship Between Histamine Release and Ca$^{2+}$ Mobilizaton in RBL 2H3 Mast Cells  

Park, Sung-Hun (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Kim, Soo-Jeong (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Kim, Jung-Min (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Park, Ju-Hyun (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Choi, Bang-Shil (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Lee, Ji-Yun (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Choi, Mi-Yeong (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Sim, Sang-Soo (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
Publication Information
YAKHAK HOEJI / v.51, no.1, 2007 , pp. 63-67 More about this Journal
Abstract
To investigate the relation between extracellular Ca$^{2+}$ and histamine release, we observed agonist-induced histamine release from RBL 2H3 mast cells in the presence or absence of extracellular Ca$^{2+}$ concentration. Histamine release induced by melittin and thapsigargin were greater in the presence of extracellular Ca$^{2+}$ than in the absence of extracellular Ca$^{2+}$. Econazole-induced histamine release had nothing to do with extracellular Ca$^{2+}$, whereas arachidonic acid-induced histamine release increased in the absence of extracellular Ca$^{2+}$. Calmodulin antagonists did not affect melittin-induced histamine release but they may potentiate arachidonic acid-induced histamine release. These data suggest that arachidonic acid-induced histamine release may be mediated via Ca$^{2+}$-independent pathway and may be potentiated by the block of Ca$^{2+}$-dependent pathway.
Keywords
mast cells; histamine; calcium; calmodulin antagonist;
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Times Cited By KSCI : 1  (Citation Analysis)
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