Browse > Article

Inhibitory Effects of Water Extract of Selaginella involvens on the Tube Formation and Invasion of Human Umbilical Vein Endothelial Cells  

Ko, Yu-Jin (College of Pharmacy, Yeungnam University)
Park, Seung-Hee (R&D Center, Jung San Biotechnology)
Lee, Yong-Hwa (R&D Center, Jung San Biotechnology)
Park, Byung-Chul (College of Pharmacy, Yeungnam University)
Hur, Jong-Hyun (R&D Center, Jung San Biotechnology)
Min, Yong-Deuk (R&D Center, Jung San Biotechnology)
Kim, Jae-Ki (R&D Center, Jung San Biotechnology)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)
Publication Information
YAKHAK HOEJI / v.51, no.1, 2007 , pp. 51-55 More about this Journal
Abstract
Among pteridophytes, Selaginella involvens Spring and Equisetum orvense L. are used in folk medicine in Eastern Asian countries including Korea. The water extracts from Selaginella involvens spring (SW) and from Equistum arvense L (EW) did not affect viability of human umbilical vein endothelial cells (HUVECs). However, SW dose-dependently inhibited tube formation and migration of HUVECs, whereas EW did not. These results suggest that the water extract from Selaginella involvens Spring may have anti-angiogenic activity.
Keywords
pteridophytes; Selaginella involvens spring; Equisetum arvense L; angiogenesis; tube formation; migration;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Yamakawa, S., Asai, T., Uchida, T., Matsukawa, M., Akizawa, T. and Oku, N. : (-)-Epigallocatechin gallate inhibits membranetype 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis. Cancer Lett. 210, 47 (2004)   DOI   ScienceOn
2 Cao, J. G., Peng, S. P., Sun, L., Li, H., Wang, L. and Deng, H. W. : Vascular basement membrane-derived multifunctional peptide, a novel inhibitor of angiogenesis and tumor growth. Acta Biochim. Biophys. Sin (Shanghai). 38, 514 (2006)   DOI   ScienceOn
3 Mousa, S. A., Mohamed, S., Wexler, E. J. and Kerr, J. S. : Antiangiogenesis and anticancer efficacy of TA138, a novel alphavbeta3 antagonist. Anticancer Res. 25, 197 (2005)   PUBMED
4 Gayathri, V., Asha, V. V. and Subramoniam, A. : Preliminary studies on the immunomodulatory and antioxidant properties of Selaginella species. Indian J. Pharmacol. 37, 381 (2005)   DOI   ScienceOn
5 Kawaguchi, T., Yamashita, Y., Kanamori, M., Endersby, R., Bankiewicz, K. S., Baker, S. J., Bergers, G. and Pieper, R. O. : The PTEN/Akt pathway dictates the direct alphaVbeta3- dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Res. 66, 11331 (2006)   DOI   PUBMED   ScienceOn
6 Rosenblatt, M. I. and Azar, D. T. : Anti-angiogenic therapy: Prospects for treatment of ocular tumors. Semin. Ophthalmol. 21, 151 (2006)   DOI   ScienceOn
7 허준. 동의보감
8 Ali, N., Yoshizumi, M., Yano, S., Sone, S., Ohnishi, H., Ishizawa, K., Kanematsu, Y., Tsuchiya, K. and Tamaki, T. : The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association. J. Pharmacol. Sci. 102, 112 (2006)   DOI   ScienceOn
9 Lin, C. M., Chang, H., Chen, Y. H., Li, S. Y., Wu, I. H. and Chiu, J. H. : Protective role of wogonin against lipopolysaccharideinduced angiogenesis via VEGFR-2, not VEGFR-1. Int. Immunopharmacol. 6, 1690 (2006)   DOI   ScienceOn
10 Yang, S. F., Chu, S. C., Liu, S. J., Chen, Y. C., Chang, Y. Z. and Hsieh, Y. S. : Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo. J. Ethnopharmacol. In Press (2006)