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Synthesis of 2-Substituted Flavone Derivatives  

Dan, On-Wha (Division of Medicinal Chemistry, College of Pharmacy, Chung-ang University)
Kim, Su-Jin (Division of Medicinal Chemistry, College of Pharmacy, Chung-ang University)
Im, Chae-Uk (Division of Medicinal Chemistry, College of Pharmacy, Chung-ang University)
Publication Information
YAKHAK HOEJI / v.50, no.6, 2006 , pp. 398-402 More about this Journal
Abstract
Flavone was found to inhibit tyrosinase and reduce synthesis of melanin to show skin-lightening effect. With the hope of identifying skin-lightening flavones, we synthesized flavone analogs. Substituted benzoic acids (1) were treated with oxalyl chloride in DMF to yield benzoyl chlorides (2), which were reacted with 2-hydroxyacetophenones (3) to afford 2-benzoyloxyacetophenones (4). These acetophenones (4) were converted into 1,3-diketones (5) with base and then treated with acid to give flavone derivatives (6).
Keywords
flavone; tyrosinase inhibitors;
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