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Effects of Chrysene on the Immune Functions in Female BALB/c Mice  

Jeon, Tae-Won (College of Pharmacy, Yeungnam University)
Kim, Chun-Hua (College of Pharmacy, Yeungnam University)
Lee, Sang-Kyu (College of Pharmacy, Yeungnam University)
Kim, Ghee-Hwan (College of Pharmacy, Yeungnam University)
Jun, In-Hye (College of Pharmacy, Yeungnam University)
Lee, Dong-Ju (College of Pharmacy, Yeungnam University)
Jeong, He-Min (College of Pharmacy, Yeungnam University)
Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University)
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YAKHAK HOEJI / v.50, no.4, 2006 , pp. 244-253 More about this Journal
Abstract
Effects of chrysene on immune functions were studied in female BALB/c mice. When mice were treated po with chrysene for 7 consecutive days, the antibody response was suppressed dose-dependently. Chrysene induced the enzyme activities of CYP LA and 2B time- and dose-dependently. In ex vivo lymphocyte proliferation, chrysene inhibited splenocyte proliferation by LPS and Con A. Moreover, the numbers of $CD4^+IL-2^+$ cells were reduced by chrysene. In conclusion, chrysene-induced immunotoxicity might be mediated, at least in part, via IL-2 production, and caused by mechanisms associated with metabolic activation.
Keywords
chrysene; immunosuppression; antibody response; metabolic activation; interleukin-2;
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