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Effects of Dipsacus asper on Free Radical Scavenging and Lowdensity Lipoprotein Oxidation  

Park Hae-Sun (College of Pharmacy, Sookmyung Women's University)
Yang Ki-Sook (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.50, no.1, 2006 , pp. 47-51 More about this Journal
Abstract
The roots of Dipsacus asper are used in traditional Chinese medicine as an analgesic, enhancement of liver activity, an anti-inflammatory agent and the treatment of fractures. In order to investigate the antioxidative activity, Dipsaci Radix was extracted with MeOH and fractionated with $CHCl_3$, EtOAc, BuOH and water. MeOH ex. and its solvent fractions were determined on the free radical scavenging activity by DPPH method and antioxidative activity on low density lipoprotein oxidation. The EtOAc and BuOH fractions showed antioxidative activities and from their fractions, two compounds were isolated and identified as hederagenin 3-O-${alpha}$-L-arabino pyranoside (compound 1) and O-${\alpha}$-L-arabinopyranosyl hed-eragenin 28-O-${\beta}$-D-glucopyranosyl ($1{\to}6$)-${\beta}$-D-glucopyranosyl ester (compound 2). Saponin glycoside, compound I showed anti-oxidative activity.
Keywords
Dipsacus asper; antioxidative activity;
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