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The Research Regarding a Prevention Effect of Osteoprosis used an Arrowroot Fermentation from Ovaryectomized SD Rat  

Ma Jin Yrul (Korea Institue of Oriental Medicine)
Lee Joung Woon (Korea Institue of Oriental Medicine)
Kim Dong-Hyun (College of Pharmacy, KyungHee University)
Lee Young Chul (Korea Food Research Institute)
Na Hye Sook (Han Zung Pharmaceutical Company)
Zee Ok Pyo (College of Pharmacy, SungKyunKwan University)
Publication Information
YAKHAK HOEJI / v.49, no.6, 2005 , pp. 495-504 More about this Journal
Abstract
In our study, osteoporosis was induced by ovariectomized in female Sprague-Daweley rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal Type I pattern was examined by using the experimental substance soybeans and arrowroot. After ovariectomy; the amount of estrogen was found to be reduced by 21.37$\%$ and it showed the tendency to be increased by 4.49$\%$ in T1 (extraction of soybeans group) and 7.62$\%$ in T2 (extraction of ferment soybeans group). The change of bone density, 14 weeks after ovariectomy in the femur, was decreased by 9.33$\%$ in N.C. group, and 5.46$\%$ in T3 (extraction of ferment arrowroot group). As pathological findings, the trabeculae of femur were detected to be abundant as normal and the frequency of the appearance of osteoclasts was very minimal. In the T3, the frequency of the appearance of the trabeculae of femur was increased to the level that could be distinguished. In regard to the accumulation of lipid in the bone marrow, the accumulation of lipid in the bone marrow was low as normal. However, in T3, the decrease to the level that could be distinguished was detected. In addition, in regard to the pathological findings of the uterus, normal uterine tissue findings were detected. In the T3, the minimal atrophy findings were detected. In conclusion, when the T3 was orally administered continuously for 14 weeks, it was thought that a certain proportion of the hormonal balance was maintained that functioned as a substance interfering the accumulation of fat, and it was considered to be of help in the treatment of not only osteoporosis Type I, but also for the prevention and treatment of various endocrinal diseases.
Keywords
fermentation; menopausal disorder; arrowroot;
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1 Kurihara, T. and Kikuchi, M. : Studies on the constituents of flowers. IV. On the components of the flower of Pueraria thubergiana Benth. (3). Yakugaku Zasshi. 96, 1486 (1976)
2 Evans, G. L., Bryant, H. U., Magee, D. E. and Tuner, R. T. : Raloxifene inhibits bone turn over and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia. Endocrinology 137, 4139 (1996)   DOI   ScienceOn
3 Scrip Reports, Dsteoporosis: research, markets, trends and opportunities. PJB Publications Ltd. pp.57-84 (1994)
4 Sharpe, R. M. and Skakkebaek, N. E.: Are oestrogen involved falling sperm counts and disorders of the male reproductive tract. Lancet 341, 1392 (1993)   DOI   ScienceOn
5 Wolff, M. S. and Weston, A. : Breast cancer risk and environmental exposure. Environmental Health Perspectioes 105, 891 (1977)
6 Faculities in Department of Herbology. Oriental Herbology. pp. 242-244, 167-168. Young-Lim Publishing Co., Seoul (1991)
7 Fotsis, T., Pepper, M., Adlercreutz, H., Flerischmann, G., Hase, T., Montesano, R. and Schweigerer, L. : Genistein a dietary derived inhibition of in vitro angiogenesis. proc. Natl. Acad. Sci. USA 90, 2690 (1993)
8 Ryan, P. J., Evans, P., Gibson, T. and Fogelman, I. : Osteoporosis and chronic back pain: A study with single-photon emission computed tomography bone scintigraphy. J. Bone Miner. Res. 7, 1455 (1992)   DOI   ScienceOn
9 Spencer, H., Rubio, N., Rubio, E., Indreika, M. and Seitam, A. : Chronic alcoholism: Frequently overlooked cause of osteoporosis in men. Am. J. Med. 80, 393 (1986)   DOI   ScienceOn
10 Waynforth, H. B. and Flecknell, P. A. : Experimental and Surgical Techniques in the Rat. Academic press (1992)
11 Saloniemi, H., Wahala, K., Nykanen-Kurki, P., Kallela, K. and Saastamoinen, I. : Phytoestrogen content and estrogenic effect of legume fodder. Proc. Soc. Exp. BioI. Med. 208, 13 (1995)
12 Nordin, B. E., Heyburn, P. J., Peacock, M. et al. : Osteoporosis and osteomalacia. Clin Endocrinol. Metab. 9(1), 177 (1980)   DOI   ScienceOn
13 Wang, W., Tanaka, Y., Han, E. and Higuchi, C. M. : Proliferative response of mammary glandular tissue to formononetin. Nutr. Cancer 23, 131 (1995)   DOI   ScienceOn
14 Bingham, S. A., Atkinson, C., Liggins, J., Bluck, A. and Coward, A. : Phytoestrogens; where are we now? Brit. J. Nutr. 79, 393 (1998)   DOI   ScienceOn
15 Consensus Conference. Osteoporosis. JAMA 252, 799 (1984)   DOI   PUBMED   ScienceOn
16 Kinjo, J., Takeshita, T., Abe, Y., Terada, N., Yamashita, H., Yamasaki, M., Takeuchi, K., Murasaki, K., Tomimatsu, T. and Nohara, T. : Studies on the constituents of pueraria lobata. IV. Chemical constituents in the flowers and the leaves. Chem. Pham. Bull. 36, 1174 (1988)   DOI
17 Bryant, H. U. and Dere, W. H. : Selective estrogen receptor modulators: an alternative to hormone replacement therapy. Proc. Soc. Exp. Bio. Med. 217, 45 (1998)
18 Lee, K. T., Sohn, I. C., Kong, E. A., Kim, D. H., Choi, S. K., Choi, J. W. and Park, H. J. : Antioxidative and cytoprotective effects of isoflavones isolated from Pueraria thunbergiana flowers. Yakhak Hoeji 43, 736 (1999)
19 Bergkvist, L., Adami, H.-O., Persson, I., Hoover, R. and Schairer, C. : The risk of breast cancer after estrogen and estrogen-progestin replacement. N. Engl. J. Med. 321, 293 (1989)   DOI   ScienceOn
20 Editorial Committee. Korean Pharmacopoeia. 7th ed. pp. 721-988. Korean Medical Index Press, Seoul, Korea (1998)
21 Forman, D. and Moller, H. : Testicular cancer. Cancer Survey 19-20, 323 (1994)