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Effect of NMDA Receptor on Analgesic Effect of Bovine Milk-derived Lactoferrin (BLF)  

Jeon, Yong-Joon (Pharmacological Research Department, National Institute of Toxicological Research)
Yun, Jae-Suk (Pharmacological Research Department, National Institute of Toxicological Research)
Lim, Hwa-Kyung (Pharmacological Research Department, National Institute of Toxicological Research)
Park, Ki-Suk (Pharmacological Research Department, National Institute of Toxicological Research)
Na, Han-Kang (Pharmacological Research Department, National Institute of Toxicological Research)
Kim, Dong-Sup (Pharmacological Research Department, National Institute of Toxicological Research)
Kim, Joo-il (Pharmacological Research Department, National Institute of Toxicological Research)
Yoon, Yea-Chang (Department of Dairy Science Graduate School of Kon-kuk University)
Choi, Ki Hwan (Pharmacological Research Department, National Institute of Toxicological Research)
Publication Information
YAKHAK HOEJI / v.49, no.5, 2005 , pp. 370-374 More about this Journal
Abstract
Lactoferrin is a multifunctional protein that is found in milk, neutrophils, and other biological fluids, and its receptors have also been identified in the central nervous system. Recently, it was reported that bovine milk-derived lacto­ferrin (BLF) produced analgesia via a $\mu$-opioid receptor-mediated response in the spinal cord. However the precise mech­anism of this analgesic effect is remains unclear. In Randall-Selitto paw pressure study, each single administration of morphine (10 mg/kg) and BLF (50, 100 and 200 mg/kg) induced analgesia, however, NMDA receptor antagonist MK-801 (0.1, 0.2 and 0.3 mg/kg), inhibited analgesia induced by BLF (100 mg/kg). Intracerebroventricular infusion (I.C.V.) of N­methyl-D-aspartic acid (NMDA) ($0.3\;{\mu}g/8.0\;{\mu}l/hr/day$), as a NMDA receptor agonist, reversed inhibition of MK-801 (0.3 mg/kg) on analgesia induced by BLF (100 mg/kg). These results suggest that BLF have analgesic effect, through NMDA recep­tor activation.
Keywords
morphine; lactoferrin; MK-801; NMDA; analgesia;
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