Neuroprotective Effect of l-Deprenyl Against 6-OHDA-Induced Dopamine Depletion in Rat Striatum and 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells |
Kim Eun-Mi
(Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University, National Institute of Scientific Investigation)
Choi Sinkyu (Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University) Lee Kyunglim (Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University) Kim Hwa-Jung (Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University) |
1 | Gerlach, M., Riederer, P. and Youdim, M. B. H. : The molecular pharmacology of l-deprenyl. European Jounal of Pharmacology-Molecular Pharmacology Section 226, 97 (1992) DOI ScienceOn |
2 | Carrillo, M. C., Kanai, S., Nokubo, M. and Kitani, K. : Deprenyl induced activities of both superoxide dismutase & catalase but not of glutathione peroxidase in the striatum of young male rat. Life Sci. 48, 517 (1991) DOI ScienceOn |
3 | Walkinshaw, G. and Waters, C. M. : Neurotoxin induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience 63, 975 (1994) DOI ScienceOn |
4 | Ochu, E. E., Rothwell, N. J. and Waters, C. M. : Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. J. Neurochem. 70, 2637 (1998) DOI ScienceOn |
5 | Knoll, J. : The striatal dopamine dependency of life span in male rats, longevity study with (-) deprenyl. Mech. Aging Dev. 46, 237 (1988) DOI ScienceOn |
6 | Cohen, G. and Spina, M. B. : Deprenyl supresses the oxidant stress associated with increased dopamine turnover. Ann. Neurol. 26, 689 (1989) DOI ScienceOn |
7 | Scarr, E., Wingerchuck, D. M., Juorio, A. V. and Paterson, I. A. : The effects of monoamine oxidase B inhibition on dopamine metabolism in rats with nigro-striatal lesions. Neurochem. Res. 19, 153 (1994) DOI ScienceOn |
8 | Leist, M. and Nicotera, P. : Apoptosis, excitotoxicity and neuropathology. Experimental Cell Reasearch 239, 183 (1998) DOI ScienceOn |
9 | Mosmann, T. : Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55 (1983) DOI PUBMED ScienceOn |
10 | Tatton, W. G. and Chalmers-Redman, R. M. E. : Modulation of gene expression rather than monoamine oxidase inhibition : (-)-Deprenyl-related compounds in controlling neurodegeneration. Neurology 47(Supple 3), S171 (1996) DOI |
11 | Kragten, E., Lalande, I., Zimmermann, K., Roggo, S., Schindler, P., Muller, D., Oostrum, J. V., Waldmeier, P. and Furst, P. : Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl. J. Biol. Chem. 273, 5821 (1998) DOI ScienceOn |
12 | Oreland, L. : Monoamine oxidase, dopamine and Parkinson's disease. Acta. Neural. Scand. 84(Suppl 136), 60 (1991) |
13 | Gerlach, M., Youdim, M. B. H. and Riederer, P. : Is selegiline neuroprotective in Parkinson's disease? J. Neural Transm [suppl]. 41, 177 (1994). |
14 | Li, X. M., Juorio, A. V., Qi, J. and Boulton, A. A. : l-Deprenyl potentiates NGF-induced changes in superoxide dismutase mRNA in PC12 cells. J. Neurosci. Res. 53, 235 (1998) DOI ScienceOn |
15 | Mochizuki, H., Goto, K., Mori, H. and Mizuno, Y. : Histochemical detection of apoptosis in Parkinson's disease. J. Neural. Sci. 137, 120 (1996) DOI ScienceOn |
16 | Marti, M. J., James, C. J., Oo, T. F., Kelly, W. J. and Burke, R. E. : Early developmental destruction of terminals in the striatal target induce apoptosis in dopamine neurons of substantia nigra. J. Neurosci. 17, 2030 (1997) |
17 | Simonian, N. A. and Coyle, J. T. : Oxidative stress in neurodegenerative disease. Annu. Rev. Pharmacol. Toxicol. 36, 83 (1996) DOI ScienceOn |
18 | Heikkila, R. and Cohen, G. : Futher syudies on the generation of hydrogen peroxide by 6-hydroxydopamine : Potentiation by ascorbic acid. Molecular Pharmacology 8, 241 (1972) |
19 | Olanow, C. and Arendash, G. : Metals and free radicals in neurodegeneration. Curr. Opin. Neurol. 7, 548 (1994) DOI ScienceOn |
20 | Spina, M. B., Squinto, S. P., Miller, J., Lindsay, R. M. and Hyman, C. : Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl 4-phenylpyridinium ion toxicity: Involvement of glutathione system. J. Neurochem. 59, 99 (1992) DOI PUBMED |
21 | Clow, A., Hussain, T., Glover, V., Sandler, M., Dexter, D. T. and Walker, M. : (-)-Deprenyl can induce soluble superoxide dismutase in rat striata. J. Neural Transm. [Gen Sect] 86, 77 (1991). DOI ScienceOn |
22 | Maruyama, W. Takahashi, T. and Naoi, M. : (-)-Deprenyl protects human doparninergic neuroblastoma SH-SY5Y cells from apoptosis induced by perowynitrite and nitric oxide. J. Neurochem. 70, 2510 (1998) DOI ScienceOn |
23 | Finberg, J. P. M., Wang, J., Goldstein, D. S., Kopin, I. J. and Bankiewics, K. S. : Influence of selective inhibition of monoamine oxidase A or B on striatal metabolism of L-DOPA in hemiparkinsonian rats. J. Neurochem. 65, 1213 (1995) DOI ScienceOn |
24 | Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. : Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265 (1951) |
25 | Wu, R. M., Chiueh, C. C., Pert, A. and Murphy, D. L. : Apperent antioxidant effect of l-deprenyl on hydroxyl adical formation and nigral injury elicited by in vivo. European Journal of Pharmacology 243, 241 (1993) DOI ScienceOn |
26 | Shimizu, S., Eguchi, Y., Kamiikie, W., Waguri, S., Uchiyama, Y., Matsuda, H. and Tsujimoto, Y. : Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: Possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene 12, 2045 (1996) |
27 | Wu, R. M., Mohanakumar, K. P., Murphy, D. L. and Chiueh, C. C. : Antioxidant mechanism and protection of nigral neurons against toxicity by deprenyl (Selegiline). Annals New York Academy of Science. 738, 214 (1994) DOI |
28 | Zuo, D. and Yu, P. H. : Increase of survival of dopaminergic neuroblastoma in co-cultures with C-6 glioma by R-(-)depreny1. Progress in Brain Research 106, 199 (1995) |
29 | Cohen, G. : Oxidative Stress in Nervous System, In Sies, H.(ed.) : Oxidative stress. Academic Press, London 383 (1985) |
30 | Breese, G. and Traylor, T. D. : Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: Evidence for selective degeneration of catecholamine neurons. J. Pharmcol. Exp. Ther. 174, 413 (1970) |
31 | Grimsby, J.. Toth, M., Chen, K., Kumazawa, T., Klaidman, L., Adams, J. D., Karoum, F., Gal, J. and Shih, J. C. : Increased stress response and -phenylethylamine in MAO-B deficient mice. Nat. Genet. 17, 206 (1997) DOI ScienceOn |
32 | Portera-Cailliau, C. and Hedreen, J. C., Price, D. L. and Koliatos, V. E. : Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J. Neurosci. 15, 3775 (1995) |
33 | Lazebnik, Y. A., Kaufman, S. H., Desnoyers, S. Poirier, G. G. and Earnshaw, W. C. : Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346 (1994) DOI ScienceOn |
34 | Le, W., Jankovic, J., Xie, W., Kong, R. and Appel, S. H. : (-)-Deprenyl protection of l-methyl-4-phenylpyridium ion ()-induced apoptosis independent of MAO-B inhibition. Neurosci. Let. 224, 197 (1997) DOI ScienceOn |
35 | Rodriguez-Gomez, J. A., Venero, J. L., Vizuete, M. L., Cano, J. and Machado, A. : Deprenyl induces the tyrosine hydroxylase enzyme in rat dopaminergic nigrostriatal system. Molecular Brain Research 46, 31 (1997) DOI ScienceOn |
36 | Maruyama, W, Naoi, M., Kasamatsu, T., Hashizume, Y., Takahashi, T., Kohda, K. and Dostert, P. An : Endogeneous dopaminergic neurotoxin, Nrnethyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells. J. Neurochem. 69, 322 (1997) DOI ScienceOn |
37 | Blum, D., Wu, Y., Nissou, M. E, Benabid, A. L. and Verna, J. M. : p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells. Brain Research 751, 139 (1997) DOI ScienceOn |