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Induction of Apoptosis by 3-Methoxy-6-Allylthiopyridazine in Human Pancreatic Cancer Cells  

Kang Young Shin (Department of Cell Physiology, NHLBI, National Institutes of Health)
Suh Yeon Won (Graduate School of Food and Drug Administration, Chung-Ang University)
Kwon Soon-Kyoung (College of Pharmacy, Duksung Women's University)
Jeong Choon Sik (College of Pharmacy, Duksung Women's University)
Lee Yong Soo (College of Pharmacy, Duksung Women's University)
Publication Information
YAKHAK HOEJI / v.49, no.4, 2005 , pp. 335-339 More about this Journal
Abstract
In this study we investigated the effect of 3-methoxy-6-allylthiopyridazine on cell growth in BxPC3 and PANC1 human pancreatic cancer cells. The treatment with 3-methoxy-6-allylthiopyridazine for 48h decreased cell viability and induced apoptotic cell death in a dose-dependent manner, assessed by using the MTT assay and the flow cytometry, respectively. These results suggest that 3-methoxy-6-allylthiopyridazine may be a good candidate for the therapeutic management of human pancreatic cancers.
Keywords
3-methoxy-6-allylthiopyridazine; pancreatic cancer cell; BxPC3; PANC1; apoptosis;
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