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Effects of Pear (Pyrus pyrifolia) Methanol Extracts on the Proliferation and the Cytokines Production of Mouse Splenocytes  

Hwang Yoo-Kyung (College of Pharmacy, Sookmyung Women's University)
Pyo Myoung-Yun (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.49, no.1, 2005 , pp. 25-29 More about this Journal
Abstract
This study was performed to investigate the potential of pear (Pyrus pyrifolia) as a immune-modulating functional food by assay of splenocytes proliferation and induction of cytokines (IFN-${\gamma}$, IL-4) in vitro. When mouse splenocytes were exposed to various concentration (0.16, 0.31, 0.63, 1.25, 2.50 mg/ml) of pear methanol extracts (P-M) without mitogens, splenocytes proliferation (SP) was significantly increased. Also, SP to mitogens, concanavalin A (Con A) and lipopolysaccharide (LPS) were significantly increased by P-M when compared with controls. When splenocytes were cultured with P-M in the presence of Con A, cytokine (IFN-${\gamma}$, IL-4) levels in culture supernatant were significantly enhanced in a dose-dependent manner except 2.5 mg/ml when compared with control group. Therefore, our study suggest that the pear has the potential of being an immune-modulating functional food.
Keywords
pear; splenocytes proliferation; IL-4;
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Times Cited By KSCI : 3  (Citation Analysis)
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