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The Prevalence of Macrolide Antibiotics Resistance in the Clinical Isolates of Common Respiratory Pathogens  

Yoon Eun-Jeong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
Ha Jang-Bum (Department of Life Science, University of Seoul)
Choi Eung-Chil (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
Shim Mi-Ja (Department of Life Science, University of Seoul)
Publication Information
YAKHAK HOEJI / v.48, no.6, 2004 , pp. 364-368 More about this Journal
Abstract
The prevalence of resistance to a range of macrolides was determined for clinical isolates of common respiratory pathogens using NCCLS testing methods and interpretative criter ia.71.4% of Streptococcus pneumoniae, 62.3% of Staphylococcus aureus, 50.8% of coagulase-negative staphylococci and 4.4% of Strpetococcus pyogenes were erythromycin resistant. Also, the rates of resistance to other macrolides and clindamycin in these clinical isolates were as high as to eryth -romycin. Almost all of the macrolide-resistant isolates were positive for erm of the methylase gene, or mef of the efflux gene.
Keywords
macrolide resistance; S. aureus; CNS; S. pyogenes; S. pneumoniae; H. influenzae; M. catarrhalis;
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