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Involvement of $\alpha_2$-Receptor in Extremely Low Frequency Magnetic Field-induced Hyperalgesia in Mice  

정지훈 (중앙대학교 약학대학 약물학실)
박해자 (중앙대학교 약학대학 약물학실)
김정수 (중앙대학교 약학대학 약물학실)
송현주 (중앙대학교 약학대학 약물학실)
손의동 (중앙대학교 약학대학 약물학실)
Publication Information
YAKHAK HOEJI / v.48, no.5, 2004 , pp. 285-290 More about this Journal
Abstract
The purpose of this study is to prove how magnetic field (MF) acts on sympathetic neuro-transmissions using thermal response. Mice were divided into two groups and each one was exposed to MF (20 G, 24 hrs) or sham. Every vehicle or drugs were treated a half hour before the thermal response test. The pain threshold was lowered by MF (20 G, 24 hrs) alone. This reduction of pain threshold by MF was not blocked by a single treatment of $\alpha$-receptor antagonist (prazosin), $\alpha$$_2$-receptor agonist (clonidine, guanabenz), $\beta$$_1$-receptor antagonist (atenolol) or $\beta$$_1$,$\beta$$_2$-receptor antagonist (propranolol). But administration of $\alpha$$_2$-receptor antagonist (yohimbine) completely inhibited the decrease in pain threshold by MF. Moreover, it increased by high dose of yohimbine over normal condition. These results suggest that MF acts on sympathetic nerve terminal to induce hyperalgesia, in which pre-synaptic az receptor might be involved.
Keywords
magnetic field; $\alpha_2$-receptor; hyperalgesia;
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