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Synthesis and Biological Evaluation as a Potential Antifungal Allylamine Derivatives  

정병호 (전남대학교 약학대학)
정순영 (전남대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.48, no.4, 2004 , pp. 254-260 More about this Journal
Abstract
Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluate the effect of naphthyl and methyl portion of naftifine. Compounds with 2,4-difluorophenyl( 2a-5a), 2,5-difluorophenyl(2b-5b), 4-ethylphenyl(2c-5c), 2-hydroxyphenyl(2d-5d) and 2-methylnaphthyl(2e-5e) instead of naphthyl group with hydrogen(3a-3e), methyl(4a-4e), and ethyl(5a-5e) in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungi. Eight compounds( 3a, 4a, 5a, 3d, 4d, 4d, 5d, 3e, and 4e) showed significant anti-fungal activity against T. mentagroPhytes. (E)-N-(3-Phenyl-2-propenyl)-2- hydroxy-benzenemethaneamine( 3d) displayed moderate antifungal activity against all five different fungi.
Keywords
trans-cinnamylamine; 2,4-difluorobenzaldehyde; 3-nitrobenzaldehyde;
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