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Design and Synthesis of Anticonvulsive Agents as Potential Dual Acting Prodrugs and Their Anticonvulsive Activities  

김은경 (영남대학교 약학대학)
최병기 (영남대학교 약학대)
김종걸 (영남대학교 약학대)
이정희 (경성대학교 약학대)
최종원 (경성대학교 약학대)
이응석 (영남대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.48, no.3, 2004 , pp. 182-188 More about this Journal
Abstract
This study aimed to synthesize new anticonvulsive agents as potential dual acting prodrugs. For the synthesis of ester or amide prodrug types, p-hydroxybenzaldehyde or valproic acid was coupled with clinically usable anticonvulsants or GABAmimetics with use of DCC/DMAP coupling methods. Also their anticonvulsive activities were evaluated.
Keywords
prodrug; anticonvulsant; GABA;
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