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Studies on the Wound Healing by the PVA-soft hydrogel  

조동현 (경성대학교 약학대학)
신영희 (경성대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.48, no.1, 2004 , pp. 55-59 More about this Journal
Abstract
A PVA-soft hydrogel, which is a semi-solid form in container, whereas after applying on the skin, it formed a thin layer within a few minutes. In this study, we prepared a novel type PVA-soft hydrogel containing 6-methyluracil as active drug, and the therapeutic value was characterized. To evaluate the therapeutic value of the PVA-soft hydrogel containing drug, various animal models, thermal burn model, incision & excision wound rat model were used. We also measured the wound size and breaking strength to calculate the wound healing extent after single or multiple administration. The wound size of soft hydrogel treated group decreased rapidly than that of control group after multiple dosing in excision wound model. And, the breaking strength of the soft hydrogel treated group was greater than that of control group in incision wound model.
Keywords
soft-hydrogel; wound healing; thermal burn model; incision & excision wound model;
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