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Effects of Acute Oral Administration of Mancozeb on the Immune Function in Mice  

정애희 (서울특별시보건환경연구원)
표명윤 (숙명여자대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.48, no.1, 2004 , pp. 41-46 More about this Journal
Abstract
Mancozeb, a polymeric complex of zinc and manganese salts of ethylene bisthiocarbamate (EBDC), is used widely in agriculture as fungicides, insecticides, and herbicides. Mancozeb can be occupationally and environmentally exposed to human and has been reported to induce estrogenic activity, therein it is considered as an endocrine disrupter, We investigated the effects of acute exposure of Mancozeb on the immune function in mice. After single oral administration of Mancozeb to female ICR mice, the immunopathological parameters (body- and organ-weight, splenic cellularity hematological parameters), mitogen (Con A, PHA+IL-2, LPS)-induced splenocyte proliferation (SP) and splenic IgM plaque forming cell (PFC). WBC and splenic cellularity were decreased, but liver-, kidney-, and spleen-weight were increased when compared with control group. Splenic IgM PFC against SRBC was slightly lowered. Mitogen-induced proliferation of spleen cells from Mancozeb-treated mice was not signifcantly changed ex vivo, however, SP in vitro were significantly lowered in concentration dependent manner. These results indicate that Mancozeb could affect the immune function in mice.
Keywords
Mancozeb; immunopathology; IgM PFC; splenocyte proliferation;
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1 /
[ Dolye,A.;Griffiths,J.B.;Newell,D.G. ] / Cell & Tissue Culture; Laboratory procedures
2 Species-and age-related differences in susceptibility to pesticide exposure for two Amphibians /
[ Harris,M.L.;Chora,L.;Bishop,C.A.;Bogart,J.P. ] / Rana pipiens, and Bufoamericanus. Bull. Environ. Contam. Toxicol.   DOI   ScienceOn
3 Enhancement of tumor-initiation activity of DMBA by the carbamate fungicide Mancozeb /
[ Mehrotra,N.K.;Kumar,S.;Yogeshwer,S. ] / Bull. Environ Contam. Toxicol.   DOI   ScienceOn
4 Subacute toxicological examination of Dithane M-45 /
[ Szepvolgyi,J.;Nagy,K.;Sajgone;Vukan,K.;Regoly-Merei,A.;Soos,K.;Toth,K.;Pinter,A.;Antal,M. ] / Fd. Chem. Toxic.   DOI   ScienceOn
5 Induction of gonadal toxicity to male rats after chronic exposure to mancozeb /
[ Kackar,R.;Srivastava,M.K.;Raizada,R.B. ] / Ind. Health   DOI   ScienceOn
6 Promoting effects of mancozeb on pancreas of nitrosomethylurea-treated rats /
[ Monis,B.;Valentich,M.A. ] / Carcinogenesis   DOI   ScienceOn
7 Effects of dentin bonding agents on macrophage mitochondrial activity /
[ Rakich,D.R.;Wataha,J.C.;Lefebvre,C.A.;Weller,R.N. ] / J. Endodon.   DOI   ScienceOn
8 Hematological values in normal laboratory mice (ICR and ddY strains) /
[ Guest,I.C.;Paik,N.W.;Ryu,J.C.;Park,J.S.;Chang,I.M. ] / Kor. J. Toxicol.
9 Imunomodulatory effects of occupational exposure to Mancozeb /
[ Colosio,C.;Barcellini,W.;Maroni,M.;Alcini,D.;Bersani,M.;Cavallo,D.;Galli,A.;Meroni,P.;Pastorelli,R.;Rozzardi,G.P.;Soleo,L.;Foa,V. ] / Arch. Environ. Health   DOI   ScienceOn
10 Studies of teratogenic effects of the dithiocarbamates Maneb, Mancozeb, and Propineb /
[ Larsson,K.S.;Arnander,C.;Cekanova,E.;Kjellberg,M. ] / Teratology   DOI   ScienceOn
11 Studies on rat thyroid after oral administration of mancozeb : morphological and biochemical evaluations /
[ Kackar,R.;Srivastava,M.K.;Raizada,R.B. ] / J. Appl. Toxicol.   DOI   ScienceOn
12 Anti-implantation effect of a carbamate fungicide mancozeb in albino mice /
[ Bindali,B.B.;Kaliwal,B.B. ] / Ind. Health   DOI   ScienceOn
13 Effect of mancozeb on ovarian compensatory hypertrophy and biochemical constituents in hemicastrated albino rat /
[ Mahadevaswami,M.P.;Jadaramkunti,U.C.;Hiremath,M.B.;Kaliwal,B. ] / Reproductive Toxicology   DOI   ScienceOn
14 One-generation reproduction toxicity study of mancozeb and lead acetate. /
[ Varnagy,L.;Budai,P.;Molnar,E.;Takacs,I.;Fejes,S. ] / Meded. Rijksuniv. Gent. Fak. Landbouwkd. Toegep. Biol. Wet.
15 /
[ 농약공업협회 ] / 농약연보
16 Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subcronic administration to C57B1/6 mice /
[ Deyo,J.A.;Kerkvliet,N.I. ] / Fundam, Appl. Toxicol.   DOI   ScienceOn
17 Effect of oral administration of fungicide-mancozeb on thyroid gland of rat /
[ Trivedi,N.;Kakkar,R.;Srivastava,M.K.;Mithal,A.;Raizada,R.B. ] / Ind. J. Exp. Biol.
18 Induction of gonadal toxicity to female rats after chronic exposure to mancozeb /
[ Baligar,P.N.;Kaliwal,B.B. ] / Ind. Health   DOI   ScienceOn
19 Further improvements in the plaque technique for detecting single antibody-forming cells /
[ Cunninghan,A.;Szenberg,A. ] / Immunol.
20 Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents /
[ Hurley,P.M.;Hill,R.N.;Whiting,R.J. ] / Environmental Health Perspectives   DOI   ScienceOn
21 Results of long-term experimental studies on the carcinogenecity of ethylene-bis-dithiocarbamate (Mancozeb)in rats /
[ Belpoggi,F.;Soffritti,M.;Guarino,M.;Lamvertini,L.;Cevolani,D.;Maltoni,C. ] / Ann. N Y Acad. Sci.   DOI