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Effect of Hexane Extract of Acori graminei Rhizoma on Chloramphenicol Acetyltransferase of Staphylococcus aureus SA2  

문경호 (경성대학교 약학대학)
권주열 (경성대학교 약학대학)
박민수 (경성대학교 약학대학)
김혜경 (경성대학교 약학대학)
이정규 (경성대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.48, no.1, 2004 , pp. 30-33 More about this Journal
Abstract
One subfraction from the hexane fraction of Acri graminei Rhizoma, the E4 fraction which is mainly consisted of acorenone, showed a potential inhibitory activity against chloramphenicol acetyltransferase (CAT) of S. aureus SA2 that is a multidrug-resistant strain to 10 usual antibiotics. The combination therapy of this fraction with chloramphenicol resulted in reduction of the minimal inhibitory concentration from 128 $\mu\textrm{g}$/ml to 8 $\mu\textrm{g}$/ml. The E4 fraction also revealed to prevent the induction of CAT from this strain.
Keywords
chloramphenicol acetyltransferase; Staphylococcus aureus SA2; growth inhibition; antibiotics resistance; resistance inhibition; Acori graminei Rhizoma; acorenone;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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