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HPLC Determination and Pharmacokinetic Profile of Ethosuximide in Korean Subjects  

배정우 (성균관대학교 약학대학)
김지홍 (성균관대학교 약학대학)
양상인 (성균관대학교 약학대학)
김현경 (성균관대학교 약학대학)
장춘곤 (성균관대학교 약학대학)
한혜원 (서울아산병원 소아과)
박영서 (서울아산병원 소아과)
손의동 (중앙대학교 약학대학)
이석용 (성균관대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.47, no.6, 2003 , pp. 444-459 More about this Journal
Abstract
Ethosuximide is an oral anticonvulsantic agent used in the first choice anti-absence seizure drug. The purpose of this study was to assess the pharmacokinetic profile of the ethosuximide in healthy Korean volunteers and to develop the efficient assay method of ethosuximide in human plasma. The pharmacokinetics of ethosuximide administered orally was evaluated after a dose of 500 mg. Ethosuximide was assayed from plasma by a specific HPLC method reading absorbance at 195 nm. AUC was 1222$\pm$160 $\mu\textrm{g}$/$m\ell$$.$hr, $C_{max}$ 14.2l$\pm$1.74 $\mu\textrm{g}$/$m\ell$, $T_{max}$ 1.06$\pm$0.62 hr and half-life 77.83$\pm$12.46 hr. The half-life in Korean was longer than, in Caucasian (53∼56 hr).).).
Keywords
ethosuximide; pharmacokinetics; HPLC;
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