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Determination of Voglibose in Pharmaceutical Preparation by Gas Chromatography  

이재윤 (경성대학교 약학과)
안문규 (경성대학교 약학과)
Publication Information
YAKHAK HOEJI / v.47, no.6, 2003 , pp. 352-355 More about this Journal
Abstract
Voglibose is a new antidiabetic agent currently being devoloped by the research and development division of Takeda chemical industries Ltd. in japan. Basic research for the determination of voglibose in pharmaceutical preparation by gas chromatography. This method utilizes voglibose to give its acyl compound with acetyl anhydride in pyridine solution. The calibration curve for voglibose was linear over the concentration range of 0.08∼0.32 $\mu\textrm{g}$/${mu}ell$ with correlation coefficient of 0.996. The detection limit for voglibose was 0.016 $\mu\textrm{g}$/${mu}ell$ and the result of recovery test was 101.6% with relative standard deviation of 2.0% by standard addition method.
Keywords
voglibose; gas chromatography; antidiabetic agent;
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