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Inhibitory Effect of Mouse Paw Edema by Solanum melongena Aqueous Extract  

김대기 (전북대학교 의과대학 면역학교실)
백옥선 (우석대학교 약학대학 한약학과, 원광대학교 약학대학 한약학과)
임종필 (우석대학교 약학대학 한약학과)
이영미 (원광대학교 약학대학 한약학과)
Publication Information
YAKHAK HOEJI / v.47, no.5, 2003 , pp. 325-330 More about this Journal
Abstract
Solanum melongena L. (Solanaceae) has anti-oxidant, analgesic, and hypolipidemic effects. We previously showed that Solanum melongena (SM) aqueous extract inhibits mast cell-mediated allergic reactions. The activation of protease-activated receptor-2 (PAR-2) induces acute inflammation in rat hindpaw. In the present study, we investigated the effects of the SM aqueous extract on mouse paw edema induced by PAR2 agonists. Trypsin or trans-cinnamoyl-LIGRLO-NH$_2$ (tc-NH$_2$), PAR-2 agonists, was injected into the hind paw of mice to induce paw edema. SM aqueous extract (1, 5, 10, and 100 mg/kg) was orally administered 1 hr before induction of paw edema. SM aqueous extract (5, 10, and 100 mg/kg) significantly inhibited both paw edema and vascular permeability in the dose-dependent manner. Furthermore, SM aqueous extract (10 mg/kg) significantly inhibited PAR-2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-$\alpha$ expression in paw tissue compared to that of saline. These results suggest that SM aqueous extract may be useful for treatment of PAR-2-mediated inflammation.
Keywords
Solanum melongena; trypsin; protease-activated receptor-2 (PAR-2); paw edema;
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