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Hypouricemic Activity of Actinidia polygama  

강효주 (경희대학교 약학대학 약물학ㆍ임상약학교실)
김유경 (경희대학교 약학대학 약물학ㆍ임상약학교실)
최진규 ((주)한국토종약초연구소)
정성현 (경희대학교 약학대학 약물학ㆍ임상약학교실)
Publication Information
YAKHAK HOEJI / v.47, no.5, 2003 , pp. 307-310 More about this Journal
Abstract
Ethanol extract of Actinidia polygama Max. (AP) was examined for hypouricemic activity in potassium oxonateinduced hyperuricemic animal model. Ethanol extract of AP lowered the plasma uric acid level by 20％ when compared to the hyperuricemic control group. AP ether fraction at a dose of 100 mg/kg showed 27％ reduction, whose efficacy was comparable to the probenecid-treated group. AP ether fraction-treated group also showed 23％ reduction of urate in urine and this result suggests that AP ether fraction has anti-gout activity probably due to xanthine oxidase inhibition.
Keywords
Actinidia polygama Max.; potassium oxonate; xanthine oxidase; gout;
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