[KSCI] Korea Science Citation Index Service

Synthesis of Quinolone Analogs of Isoflavonoids

전라옥 (숙명여자대학교 약학대학)
이지혜 (숙명여자대학교 약학대학)
정상헌 (충남대학교 약학대학)

Publication Information

YAKHAK HOEJI / v.47, no.5, 2003 , pp. 283-287 More about this Journal

Abstract

Isoflavonoids are abundant in natural products and reported with many synthetic variations. However, relatively few quinolone analogs of isoflavonoids have been described. As part of our endeavor to pursue biologically active novel isoflavonoids, we report an efficient synthetic route for quinolone analogs of isoflavonoids. The key intermediate, 2'-aminochalcone 2 was obtained from substituted aniline and cyclized to afford quinolones 6, 8a, and 8b.

Keywords

quinolone; isoflavone; 2′-aminochalcone;

Citations & Related Records

Reference

1	Effects of phytoestrogens on aromatase, 3β and 17β-hydro-xysteroid dehydrogenase activities and human breast cancer cells / [ Le Bail, J. C.;Champavier,Y.;Chulia,A.J.;Habrioux,G. ] / Life Sciences DOI
2	Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action / [ Matsuda,H.Morikawa,T.;Ando,S.;Toguchida,I.;Yoshikawa,M. ] / Bioorganic & Medicinal Chemistry DOI ScienceOn
3	The in vivo antioxidant activity of soybean isoflavones in human subjects / [ Fritz,K.L.;Seppanen,C.M.;Kurzer,M.S.;Csallany,A.S. ] / Nutrition Research DOI ScienceOn
4	Synthesis of novel 3,7-substituted-2-(3´,4´-dihydroxyphenyl)flavones with improved antioxidant acivity / [ Van Acker, F. A. A.;Hageman,J.A.;Haenen,G.R.M.M.;Van der Vijgh, W. J. F;Bast,A.;Menge,W.M.P.B. ] / J. Med. Chem. DOI ScienceOn
5	Dietary agents in cancer prevention: flavonoids and isoflavonoids / [ Birt,D.E.;Hendrich,S.;Wang,W. ] / Pharmacology & Therapeutics DOI ScienceOn
6	Flavonoids can block PSA production by brest and prostate cancer cell lines / [ Fosenberg Zand, R. R.;Jenkins,D.J.A.;Brown,T.J.;Damandis,E.P. ] / Clinica Chimica Acta DOI
7	Effects of naturally occurring flavonoids on nitic oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships / [ Kim,H.K.;Cheon,B.S.;Kim,Y.H.;Kim,S.Y.;Kim,H.P. ] / Biochemical Pharmacology DOI
8	Strategies toward the design of novel and selective protein tyrosine kinase inhibitors / [ Traxler,P.;Furet,P. ] / Pharmacology & Therapeutics DOI ScienceOn
9	A class of semi-essential food components: their role in human nutrition / [ Kuhnau,J. ] / World Review of Nutrition Diet
10	Isoflavonoid compounds from red clover (Trifolium pratense) protect from inflammation and immue suppression induced by UV radiaton / [ Widyarini,S.;Spinks,N.;Husband,A.J.;Reeve,V.E. ] / Photochemistry and Photobiology DOI ScienceOn
11	Aromatase and 17β-hydroxysteroid dehydrogenase inhibition by flavonoids / [ Le Bail, J. C.;Laroche,T.;Marre-Fournier, F.;Habrioux,G. ] / Cancer Letters DOI ScienceOn
12	Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging / [ Patel,R.P.;Boersma,B.J.;Crawford,J.H.;Hogg,N.;Kirk,M.;Kalyanaraman,B.;Parks,D.A.;Barnes,S.;Darley-Usmar,V. ] / Free Radical Biology and Medicine DOI ScienceOn
13	Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica / [ Waffo,A.K.;Azebaze,G.A.;Nkengfack,A.E.;Fomum,Z.T.;Meyer,M.Bodo,B.;Heerden,F.R. ] / Phytochemistry DOI ScienceOn
14	Antifungal activity of isoflavonoids in different reduced stages on Rhizoctonia solani and Sclerotium rolfsii / [ Weidenborner,M.;Hindorf,H.;Jha,H.C.;Tsotsonos,P.;Egge,H. ] / Phytochemistry DOI ScienceOn
15	Anti-tumor-promoting effects of isoflavonoids on epstein-barr activation and two-stage mouse skin carcinogenesis / [ Eo,C.;Itoigawa,M.;Tan,H.T.W.;Tokuda,H.;Mou,X.Y.;Mukainaka,T.;Ishikawa,T.;Nishino,H.;Furukawa,H. ] / Cancer Letters DOI ScienceOn
16	Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica / [ Min,B.G.;Oh,S.R.;Lee,H.K.;Takatsu,K.;Chang,I.M.;Min,K.R.;Kim,Y.S. ] / Planta Medica DOI ScienceOn
17	Recent pharmacological results on bioflavonoids / [ Wagner,H.;Lacaille-Dubois,M.A.;Antus,S.(ed.);Gabor,M.(ed.)Vetschera,K.(ed.) ] / Akademiai Kiado, Budapest. Flavonoids and bioflavonoids. Proceedings of the International Bioflavonoids Symposium
18	Isoflavonoids and Lignans in Legumes: Nutritional and Health Aspects in Humans / [ Mazur,W.M.;Duke,J.A.Wahala,K.;Rasku,S.:Adlercreutz,H. ] / The Journal of Nutritional Biochemistry DOI ScienceOn

KSCI

Synthesis of Quinolone Analogs of Isoflavonoids 퀴놀론 계열 이소플라보노이드의 합성

Synthesis of Quinolone Analogs of Isoflavonoids