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Analysis of 3,4-Methylendedioxymethamphetamine (MDMA) in Human Hair by Gas Chromatography/Mass Spectrometry  

박미정 (국립과학수사연구소 법과학부)
김은미 (국립과학수사연구소 법과학부)
임미애 (국립과학수사연구소 법과학부)
정희선 (국립과학수사연구소 법과학부)
Publication Information
YAKHAK HOEJI / v.47, no.4, 2003 , pp. 195-199 More about this Journal
Abstract
An analysis method for the determination of methylendedioxymethamphetamine (MDMA) and its metabolite methylendedioxymethamphetamine (MDA) in hair by gas chromatography/mass spectrometry was proposed. For MDMA and MDA analysis, hair samples were incubated in MeOH (1％ HCl), derivatized with trifluoroacetic anhydride and assayed by GC/MS. Hair of 18 subjects for drug abuse was analyzed for MDMA and MDA. Calibration curves for the determination of MDMA and MDA in hair showed a good linearity at a concentration range from 0.5 ng to 250 ng ($r^2$=0.999) The extraction recovery was determined from hair blanks at 50, 100 ng. The percentage of recovery were found to be 96.08∼103.48 with CV value of 1.62∼3.89. The concentrations of MDMA and MDA ranged 1.14∼38.06 ng/mg and 0.07∼3.91 ng/mg, respectively in 18 hair samples from MDMA abusers. The ratio of MDMA to MDA ranged from 9.65∼28.46 in all specimen. Hair analysis for MDMA is a useful method for identification of long-term drug abuser.
Keywords
methylendedioxymethamphetamine (MDMA); methylenedioxyamphetamine (MDA); hair analysis; GC/MS;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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