Browse > Article

Simultaneous Determination of Amphetamine-Type Stimulants (ATS) in Human Hair by GC-MS  

김진영 (대검찰청 마약감식실)
서승일 (대검찰청 마약감식실)
고범준 (대검찰청 마약감식실)
이재일 (대검찰청 마약감식실)
정재철 (대검찰청 마약감식실)
서용준 (대검찰청 마약감식실)
인문교 (대검찰청 마약감식실)
Publication Information
YAKHAK HOEJI / v.47, no.3, 2003 , pp. 142-147 More about this Journal
Abstract
Gas chromatography-mass spectrometric (GC-MS) procedure is presented for the simultaneous qualification and quantitation of methamphetamine (MA), amphetamine (AMP), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), and 3,4-methylenedioxyethylamphetamine (MDEA) in human hair. The method procedure involves decontamination of hair with distilled water and acetone, acidic hydrolysis, extraction in the presence of deuterated internal standards, and GC-MS analysis after derivatization with trifluoroacetic anhydride (TFAA) in ethylacetate. The limit of detection for 5 drugs were about 0.1∼0.15 ng/mg using 30 mg hair sample. Coefficient variations of correlation ranged from 0.9941 to 0.9993. The recoveries of these drugs were found to be 93.4∼104.4％. The concentrations of AMP, MA, MDA, and MDMA in abusers' hair samples were measured 0.17∼2.88, 2.09∼18.34, 0.24∼3.83, and 3.10∼22.81 ng/mg, respectively. The ratios of MA/AMP and MDMA/MDA ranged 5.67∼49.57 and 4.78∼54.31, respectively. This assay has been successfully utilized in the evaluation of the deposition of amphetamine-type stimulants (ATS) in human hair.
Keywords
ATS; methamphetamine; amphetamine; MDMA; MDA; MDEA; hair; GC-MS;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Detection of basic drugs (methamphetamine, antidepressants, and nicotine) from human hair /
[ Ishiyama, I.;Nagai, T.;Toshida, S. ] / J. Forensic Sci.
2 Fatalities caused by the MDMA-related drug paramethoxyamphetamine (PMA) /
[ Kraner, J. C.;MacCoy, D. J.;Evanes, M. A.;Evanes, L. E.;Sweeney, B. J. ] / J. Anal. Toxicol.   DOI   ScienceOn
3 Hair analysis as evidence in forensic cases /
[ Moeller, M. R.;Fey, P.;Sachs, H. ] / Forensic Sci. Int.   DOI
4 Determination of chronic methamphetamine abuse by hair analysis /
[ Saito, T.;Yamamoto, I.;Kusakabe, T.;Huang, X. L.;Yukawa, N.;Takeichi, S. ] / Forensic Sci. Int.   DOI   ScienceOn
5 Determination of methamphetamine and amphetamine in biological fluids and hair by gas chromatography /
[ Takahashi, K. ] / Nippon Hoigaku Zasshi
6 GC/MS를 이용한 모발 중 MDMA의 분석 /
[ 정희선;박미정;김은미;이재신;유영찬 ] / 한국법과학회지
7 Hair-a biological source in drug analysis /
[ Skender, L. ] / Arh. Hig. Rada. Toksikol.
8 Hair analysis for drug abuse: Ⅰ. Determination of methamphetamine and amphetamine in hair by stable isotope dilution gas chromatography/mass spectrometry method /
[ Nakahara, Y.;Takahashi, K;Shimamine, M.;Takeda, Y. ] / J. Forensic Sci.
9 Detection of methamphetamine and amphetamine in a single human hair by gas chromatography/chemical ionization mass spectrometry /
[ Suzuki, O.;Hattori, H.;Asano, M. ] / J. Forensic Sci.
10 The detection of 6-mono-acetylmorphine in urine, serum, and hair by GC/MS and RIA /
[ Moeller, M. R.;Mueller, C. ] / Forensic Sci. Int.   DOI
11 Hair analysis for drugs of abuse: XV. Disposition of 3,4-methylenedioxy-methamphetamine (MDMA) and its related compounds into rat hair and application to hair analysis for MDMA abuse /
[ Kikura, R.;Nakahara, Y.;Mieczkowski, T.;Tagliaro, F. ] / Forensic Sci. Int.   DOI
12 MDA-MDMA Concentrations in Urine specimens /
[ Kunsman, G. W.;Levine, B.;Kuhlman, J. J.;Jones, R. L.;Hughes, R. O.;Fujiyama, C. L.;Smith M. L. ] / J. Anal. Toxicol.   DOI   ScienceOn
13 Determination of amphetamine and methylenedioxy-amphetamine-derivatives in hair /
[ Rohrich, J.;Kauert G. ] / Forensic Sci. Int.   DOI
14 Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine /
[ Gudelsky, G. A.;Yamamoto, B. K. ] / Methods Mol. Med.
15 Simultaneous hair testing for opiates, cocaine, and metabolites by GC-MS: a survey of applicants for driving licenses with a history of drug use /
[ Montagna, M.;Stramesi, C.;Vignali, C.;Groppi, A.;Polettini, A. ] / Forensic Sci. Int.   DOI
16 GC/MS analysis of drugs and metabolites in hair for diagnosis of chronic drug abuse /
[ Nakahara, Y.;Kikura, R.;Konuma, K. ] / Adv. In Chem. Diagnos. Treat. of Metab. Disord
17 The use of hair analysis to document a cocaine overdose following a sustained survival period before death /
[ Martz, R. L.;Donnelly, B.;Fetterolf, D.;Lasswell, L.;Hime, G. W.;Hearn, W. L. ] / J. Anal. Toxicol.   DOI   ScienceOn
18 Simultaneous determination of drugs of abuse (opiates, cocaine and amphetamine) in human hair by GC/MS and its application to a methadone treatment program /
[ Moeller, M. R.;Fey, P.;Wennig, R. ] / Forensic Sic. Int.   DOI
19 Human psychopharmacology of ecstasy (MDMA): a review of 15 years of empirical research /
[ Parrott, A. C. ] / Hum. Psychopharmacol   DOI   ScienceOn
20 Simultaneous Determination of amphetamine, methamphetamine, 3,4-methylenedioxy-amphetamine and 3,4methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry /
[ Kintz, P.;Cirimele, V.;Tracqui, A.;Mangin, P. ] / J. Chromatogr. B.(Biomed. Appl.)   DOI   ScienceOn