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Solid Lipid Microspheres for Controlled Release Abdominal Injection of Local Anesthetic  

박용근 (충남대학교 약학대학)
이종화 (충남대학교 약학대학)
김동우 (충남대학교 약학대학)
윤재남 (충남대학교 약학대학)
전일순 (충남대학교 약학대학)
이은미 (충남대학교 약학대학)
이계원 (건양대학교 제약공학과)
지웅길 (충남대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.47, no.2, 2003 , pp. 78-84 More about this Journal
Abstract
Local anesthetics are used to reduce pain, but they are so frequently injected to patients. So, we prepared lidocaine solid lipid microspheres (SLM) as long acting abdominal injection using spray drying method and evaluated drug entrapment, particle size, SEM, zeta potential and in vitro and in vivo drug release pattern, The particle sizes of SLM were 30∼100$\mu$m and it is enough to inject into abdominal tissue. The entrapment efficiency of SLM was over 95％ as spray drying method. Surfactant and PC decreased the burst effect by 20∼30％. In in vivo test, C-6 showed controlled release concentration profile in plasma for 8 days and C-5 sustained longer than we expected.
Keywords
Solid lipid microspheres (SLM); spray drying method; lidocaine;
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