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Effects of Citrus Essential Oils on Melanin Production in B16 Melanoma Cells  

임혜원 (중앙대학교 의약식품대학원)
조남영 (중앙대학교 의약식품대학원)
윤미연 (중앙대학교 의약식품대학원)
차상복 (중앙대학교 의약식품대학원)
김경원 (중앙대학교 의약식품대학원)
박영미 (중앙대학교 의약식품대학원)
이지윤 (중앙대학교 약학대학)
이진희 (중앙대학교 약학대학)
김창종 (중앙대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.47, no.1, 2003 , pp. 25-30 More about this Journal
Abstract
This study is performed to investigate the effects of citrus essential oils on melanin production in B16 melanoma cells. Five kinds of citrus essential oils (Bergamot, Grapefruit, Lemon, Mandarin, Petigrain) did not have any influence on DPPH radical scavenger activity, cell growth and cytotoxicity in B16 melanoma cells. Both mandarin and petigrain essential oils dose-dependently inhibited purified tyrosinase activity, but bergamot did not. In 1$\mu$M MSH-stimulated B16 melanoma cells, all of 5 citrus essential oils inhibited melanin production in a dose dependent manner. From the above results, it is possible that citrus essential oils may be developed to be an anti-melanogenesis agent on the basis of their inhibitory effect on MSH-induced melanin production.
Keywords
Melanin; tyrosinase; citrus essential oil;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
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