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Vanadate-induced Platelet Aggregation and Inhibition Effect of Vanadium Yeast  

박승희 (식품의약품안전청)
오승민 (성균관대학교 약학대학)
박영현 (순천향대학교 식품영양학과)
정규혁 (성균관대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.46, no.6, 2002 , pp. 441-447 More about this Journal
Abstract
It has been well known that vanadium shows various physiological and pharmacological properties such as an insulin-mimetic effect. In view of the reported toxic effects there is the problems that the safety margin is narrow because of its strong toxicity, Vanadate was tested for its ability to cause blood aggregation. Although vanadate or $H_2O$$_2$ alone had little effect on platelet aggregation, treatment of vanadate and $H_2O$$_2$ together induced platelet aggregation indicated that it was occurred by pervandate or hydroxyl radical produced from the reaction of vanadate and $H_2O$$_2$. It was dependent on extracellular $Ca^{2+}$ion. Platelet aggregation caused by vanadate and $H_2O$$_2$ was inhibited by ascorbic acid, tocopherol, catalase, mannitol, and Tiron. In contrast to vanadate, vanadium yeast prepared by uptaking vanadate in yeast cells did not induce platelet aggregation in the presence of $H_2O$$_2$.>.
Keywords
Vanadate; vanadium yeast; platelet aggregation;
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