Browse > Article

Isolation of the Efficacy Constituent for Neuronal Regeneration from Cibotium barometz  

김상태 (지젠생명공학연구소)
한용남 (서울대학교 천연물과학연구소)
손연경 (서울대학교 천연물과학연구소)
장형석 (자생한방병원)
김수장 (자생한방병원)
신준식 (자생한방병원)
Publication Information
YAKHAK HOEJI / v.46, no.6, 2002 , pp. 398-404 More about this Journal
Abstract
A phytochemical study on the root of Cibotium barometz J. Smith led to the isolation of onitin (I), daucosterol (II) and a new compound (III). Compound III was characterized as 2-Ο-(9Z,12Z-octadecadienoyl)-3-Ο-[$\alpha$-D-galactopyranosyl-(1"-6")-Ο-$\beta$-D-galactopyranosyl] glycerol, named shinbarometin by $^1$H-, $^{13}$ C-NMR and LC/MS data. Compound III exerted an induced neuronal regeneration on nogo-A induced neuroblastoma cells.
Keywords
Cibotium barometz (L.) J. Smith; monoacylglyceryl; dι-galactoside; shinbarometin; neuronal regeneration;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Murakami, T., Satake, T., Ninomiya K., Iida, H., Yamauchi, K., Tanaka, N., Saiki, Y., and Chen, CM. : Pterosin-derivate aus der Famile Pteridaceae. Phytochemistry 19, 1743 (1980)
2 Chen, M. S., Huber, A. B., van der Haar, M. E., Frank, M., Schnell, L., Spillmann, A. A., Christ, E, and Schwab, M. E. : Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434 (2000)
3 GrandPre, T., Nakamura, F., Vartanian, T., and Strittmatter, S. M. : Identification of the nogo inhibitor of axon regeneration as a reticulon protein. Nature 403, 439 (2000)
4 Domeniconi, M., Cao, Z., Spencer, T., Sivasankaran, R., Wang, K., Nikulina, E., Kimura, N., Cai, H., Deng, K., Gao, Y., He, Z., and Filbin, M. : Myelin-associated glycoprotein interacts with the nogo66 receptor to inhibit neurite outgrowth. Neuron 35, 283 (2002)
5 Wang, K. C., Koprivica, V., Kim, J.A., Sivasankaran, R., Guo, Y., Neve, R. L., and He, Z. : Oligodendrocyte-myelin glycoprotein is a nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941 (2002)
6 Zuo, J., Neubauer; D., Graham, J., Krekoski, C. A., Ferguson, T. A., and Muir, D. : Regeneration ofaxons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan. Exp. Neuron 176, 221 (2002)
7 Mey J., Rombach N. : Retinoic acid increases BDNF-dependent regeneration of chick retinal ganglion cells in vitro. Neuroreport Nov 26; 10(17), 3573 (1999)
8 Wickelgren, D. : Neuroscience. Animal studies raise hopes for spinal cord repair. Science 297, 178 (2002)
9 Prinjha, R., Moore, S. E., Vinson, M., Blake, S., Morrow, R., Christie, G., Michalo rich, D., Simmons, D. L., and Walsh, F. S. : Neurobiology, Inhibitor of neurite outgrowth in humans. Nature 403, 383 (2000)
10 Stothers, J. B. : carbon-$^{13}NMR$ Spectroscopy. Academic Press, New York (1972)
11 Namba, T. The Encyclopedia of Wakan-Yaku with Color Pictures(I), Hoikusha Pub. Co., Osaka, 86 (1993)
12 ‘Directory of Chinese Materia Medica' (Zhong Yao Da Ci Dian or 中藥大辭典) ed. by Jiansu New Medical College, Shanghai Scientific and Technollgical Publisher, Shanghai, p.1420 (1977)
13 Yang, M. S. : Studies on the Taiwan fork medicine VI. Studies on onitin. Planta Medica p 25 (1986)
14 Tessier-Lavigne, M., and Goodman, C. S. : Perspectives neurobiology. regeneration in the nogo zone. Science 287, 813 (2000)
15 Liu, B. P., Fournier, A., GrandPre, T., and Strittmatter, S. M. : Myelin-associated glycoprotein as a functional ligand for the nogo-66 receptor. Science. 297, 1190 (2002)   DOI   PUBMED   ScienceOn
16 Janiga T.A., Rind H. B., von Bartheld C. S. : Differential effects of the trophic factors BDNF, NT-4, GDNF, and IGF-I on the isthmo-optic nucleus in chick embryos. J. Neurobiol Jun 5; 43(3), 289-303 (2000)
17 Jung, J. H., Lee H. K., and Kang, S. S. : Diacylglycerylga-lactosides from Arisaema amurense. Phytochemistry 42, 447 (1996)