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$\beta$-Lactamase Inhibitory Activity and Comparative Activity of Sulbactam Derivatives Combined with $\beta$-Lactam Antibiotics  

임채욱 (중앙대학교 약학대학 의약품화학 교실)
박희석 (중앙대학교 약학대학 의약품화학 교실)
김용현 (중앙대학교 약학대학 의약품화학 교실)
임철부 (중앙대학교 약학대학 의약품화학 교실)
Publication Information
YAKHAK HOEJI / v.46, no.6, 2002 , pp. 387-391 More about this Journal
Abstract
In vitro $\beta$-lactamase inhibitory activity of 6-exomethylene sulbactam compounds (CH-120, 130, 140, 145, 150, 155) was compared with clavulanic acid, sulbactam and tazobactam. The inhibitory activity of CH-140 was stronger than sulbactam and clavulanic acid against Type II, III, IV, TEM enzymes and stronger than tazobactam against Type IV enzyme. The inhibitory activity of CH-145 was stronger than sulbactam and clavulanic acid against Type I, II, III, IV, TEM enzymes and stronger than tazobactam against Type III, IV enzymes. The in vitro antimicrobial activity of CH-140 and CH-145 combined with piperacillin and ceftriaxone was compared with the sulbactam and tazobactam against $\beta$-lactamase producing 31 strains. But, synergistic activity of CH-140 and CH-145 was inferior to tazobactam.
Keywords
Antimicrobial activity; $\beta$-Lactamase inhibitors;
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