In vitro Antiinflammatory Activity of the Essential Oil from Ligularia fischeri var. spiciformis in Murine Marcrophage Raw 264.7 Cells
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김륭규
(경희대학교 약학대학)
신경민 (경희대학교 약학대학) 천성국 (경희대학교 약학대학) 지사영 (경희대학교 약학대학) 서성훈 (경희대학교 약학대학) 박희준 (상지대학교 응용식물과학부) 최종원 (경성대학교 약학대학) 이경태 (경희대학교 약학대학) |
1 | Moncada, S., Palmer, R. M. and Higgs, E. A. : Nitric oxide: physiology. pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109 (1991) |
2 | McCartney-Francis, N., Allen, J. B., Mizel, D. E., Albina, J. E., Xie, Q. W., Nathan, C. F. and Wahl, S. M. : Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 178, 749 (1993) DOI ScienceOn |
3 | Wang, W. S., Gao, K., Yang, L. and Jia, Z., J. : Eremophilenolides from Ligularia fischeri. Planta Med. 66, 189 (2000) |
4 | Vane, J. R. : Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New. Biol. 23, 232 (1971) |
5 | Knowles, R. G. and Mocada, S. : Nitric oxide as a signal in blood vessels. TIBS. 17, 399 (1992) |
6 | Feldmann, M., Brennan, F. M. and Maini, R. N. : Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397 (1996) DOI ScienceOn |
7 | Duerksen-Hughes, P. J., Day, D., Laster, S. M. A., Zacharidaes, N. A., Aquino, L. and Gooding, L. R. : Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40-transformed cells by activated macrophages J. Immunol. 149, 2114 (1992) |
8 | Choi, O. J. : Usage and Constituents of Medicinal Plants. Ilweolseogak, Seoul, p. 62 (1991) |
9 | Kuhara, K, Takanashi, H., Hirono, I., Furuya, T. and Asada, Y. : Carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata. Cancer Lett. 10, 117 (1980) DOI ScienceOn |
10 | Masferrer, J., Zweifel B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C. and Seibert, K. : Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. U.S.A. 91, 3228 (1994) DOI ScienceOn |
11 | Park. H. J., Lee, K. T., Jung, W. T., Choi, J. W. and Kadota, S. : Protective Effects of syringin isolated from Kalopanax pictus on galactosamine induced hepatotoxicity, Natural Medicine. 53, 113 (1999) |
12 | Harada, A., Sekido, N., Akahoshi, T., Wada,T., Mukaida, N. and Matsushima, K. J.: Essential involvement of interleukin-8 (IL-8) in acute inflammation. J. Leukoc. Biol. 56, 559 (1994) |
13 | Stuehr, H. H. J., Kwon, N. S., Weise, M. and Nathan, C. : Purification of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc. Natl. Sci. USA. 88, 7771(1991) |
14 |
Weisz, A., Cicatiello, I. and Esumi, H. : Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-gamma, bacterial lipopolysaccharide and |
15 | Nathan, C. : Nitric oxideas a secretory product of mammalian cells. FASEB J. 6, 3051 (1992) |
16 | Willeaume, V., Kruys, V., Mijatovic, T. and Huez, G. : Tumor necrosis factor-alpha production induced by viruses and by lipopolysaccharides in macrophages: similarities and differences. J. Inflamm. 46, 1 (1995) |
17 | Kim, Y. K., Kim, R. G., Park, S. J., HA, J. H., Choi, J. W., Park H. J. and Lee, K. T. : In vitro antiinflammatory activity of kalopanaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells. Biol Pharm Bull. 25, 472 (2002) |
18 | Seibert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L. and Ksakson, P. : Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. U.S.A 91, 12013 (1994) |
19 | Funk, C. D., Frunk, L. B., Kennedy, M. E., Pong, A. S. and Fitzgerald, G. A. : Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J. 5, 2304 (1991) |
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