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Determination of Acidic Drug with ISEs Using Ternary Complex of Metal-di-2-pyridyl Ketone Oxime-acidic Drug as Ion-Exchanger  

안문규 (경성대학교 약학대학)
오원정 (경성대학교 약학대학)
이언경 (경성대학교 약학대학)
이순영 (경성대학교 약학대학)
이재윤 (경성대학교 약학대학)
정문모 (경성대학교 약학대학)
허문회 (부산지방식품의약품안전청)
Publication Information
YAKHAK HOEJI / v.46, no.5, 2002 , pp. 320-323 More about this Journal
Abstract
A method for the determination of acidic drug, mefenamic acid and ibuprofen with ion-selective electrode(ISE) using Fe(II)-di-2-pyridyl ketone oxime complex as a counter ion were developed. Benzyl-2-nitrophenyl ether(BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. The acidic drug selective electrode exhibits a linear response for 10$^{-2}$ M 510$^{-5}$ M of acidic drugs, mefenamic acid and ibuprofen with a slope of -55.9 and -56.3 mV/dec. in borate buffer solution (pH 8.9). Potentiometric selectivity measurements revealed negligible interferences from aromatic and aliphatic carboxylic acid salts. The electrodes were found to be useful for the direct determination of mefenamic acid and ibuprofen in pharmaceutical preparations.
Keywords
ISE; mefenamic acid; ibuprofen; Fe(II)-di-2-pyridyl ketone oxime;
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