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Lupane Derivatives-I: Synthesis and Cytotoxic Activity  

You, Young-Jae (College of Pharmacy, Chungnam National University)
Kim, Yong (College of Pharmacy, Chungnam National University)
Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
Publication Information
YAKHAK HOEJI / v.46, no.5, 2002 , pp. 295-300 More about this Journal
Abstract
To observe the structure-activity relationship of lupane derivatives both on cytotoxic and antiangiogenic activity, twelve lupane derivatives were prepared; their antiangiogenic and cytotoxic activities were evaluated. Among them, four compounds were more cytotoxic than betulinic acid. Carboxylic acid at C28 seemed to be essential for cytotoxic activity. But, a selective cytotoxicity toward SK-MEL-2 was not observed. As for antiangiogenic activity, none of the compounds except lupeol showed antiangiogenic activity at 30 $\mu\textrm{g}$/mL.
Keywords
Lupane; lupeol; betulin; betulinic acid; cytotoxicity; antiangiogenesis;
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