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Metabolic Phenotyping and Genotype of Dextromethorphan in Korean  

정희선 (국립과학수사연구소)
양원경 (국립과학수사연구소)
최화경 (국립과학수사연구소)
양영근 (국립과학수사연구소)
한은영 (국립과학수사연구소)
정운계 (인하대학교 의과대)
유영찬 (국립과학수사연구소)
Publication Information
YAKHAK HOEJI / v.46, no.3, 2002 , pp. 179-184 More about this Journal
Abstract
The abuse of dextromethorphan has been prevalent for 15 years in Korea and its fatal cases were reported even though it has proved to be very safe. In this study, to investigate the safety and tolerance assessment of dextromethorphan, the metabolic phenotyping and genotype of dextromethorphan were studied. After a single 30 mg of dextromethorphan oral administration to 74 volunteers, concentration of dextromethorphan and its metabolites, dextrorphan, hydroxymorphinan and methoxymorphinan were measured in urine which collected during 8hrs after the drug administration. CYP2D6 phenotype was determined from the ratio of dextromethorphan to dextrorphan. GC/MS was used to quantify dextromethorphan and its metabolites. For genotyping, mutant alleles of the CYP2D6 gene were identified. 24 subjects (32.4％) were homozygous for CYP2D6＊10B, 29 subjects (39.2％) were heterozygous for this allele, while in 21 subjects (28.4％) no exon 1 mutation could be found. The frequency of CYP2D6＊10B-allele containing the 188C T mutation was 54％ of total subjects studied.
Keywords
drug abuse; dextromethorphan; dextrorphan; CYP2D6 phenotype; genotype;
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