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Synthesis of 4,5-substituted 3-alkoxy-6-allylthiopyridazine Derivatives  

권순경 (덕성여자대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.46, no.3, 2002 , pp. 155-160 More about this Journal
Abstract
Through a modification of allicin structure a disagreeable odor and chemical instability of allicin can be improved. 3-Alkoxy-6-allylthiopyridazine derivatives exhibit a superior effect for prevention and treatment of hepatic diseases induced by carbon tetrachloride and aflatoxin B1 and for prevention of human tissues from radiation. These compounds inhibit also efficiently SK-Hep-1 cell proliferation through induction of apoptosis. So another 4,5-mono- or di-substituted 3-alkyloxy-6-allylthiopyridazine derivatives were synthesized on purpose to find out SAR of allylthiopyridazine in hepatoprotective and hepatotherapeutic acitivitis and to develop more effective drug candidate.
Keywords
Pyridazine; alkoxyallylthiopyridazine; aryloxyallylthiopyridazine; hepatoprotective; hepatotherapeutic; SK- Hep-1 cell; aflatoxin B1; 1,2-diazine;
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